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Selective molecular and network architecture features underlie brain cortical atrophy in dementia with Lewy bodies [PDF]

Journal of Biomedical Science
Background Dementia with Lewy bodies shares clinical and pathological features with both Parkinson’s disease and Alzheimer’s disease, but the local biological factors that render specific cortical regions vulnerable to atrophy remain poorly defined.
Aline Delva, Stephen Joza, Christina Tremblay, Andrew Vo, Marie Filiatrault, Madeleine Carrier, John-Paul Taylor, John T. O’Brien, Michael Firbank, Alan Thomas, Paul C. Donaghy, Richard Camicioli, Howard Chertkow, Alain Dagher, Ronald B. Postuma, Shady Rahayel   +15 more
doaj   +3 more sources

From engagement to dissemination: a WiseAge patient and public involvement and engagement event on dementia with Lewy bodies [PDF]

Frontiers in Dementia
BackgroundDementia with Lewy bodies may account for up to 20% of dementia cases, yet public awareness remains limited. Public engagement may help communicate dementia research to wider audiences, but little is known about whether information spreads ...
Jon Arild Aakre, Jon Arild Aakre, Arvid Rongve, Arvid Rongve, Kari Fredriksen, Ellen J. Svendsboe, Ingelin Testad, Ingelin Testad   +7 more
doaj   +2 more sources

Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study

Biology of Sex Differences, 2022
Highlights There are significant sex differences in Chinese population with cognitive impairment in Lewy body disease. Women were more common in dementia with Lewy bodies and mild cognitive impairment with Lewy bodies cases, had more frequent and severe ...
Jinghuan Gan, Zhichao Chen, Zhihong Shi, Xudong Li, Shuai Liu, Yiming Liu, Hongcan Zhu, Lu Shen, Guili Zhang, Yong You, Qihao Guo, Nan Zhang, Yang Lv, Baozhi Gang, Junliang Yuan, Yong Ji   +15 more
doaj   +1 more source

I-Metaiodobenzylguanidine Myocardial Scintigraphy in Lewy Body-Related Disorders: A Literature Review [PDF]

Journal of Movement Disorders, 2015
Lewy body-related disorders are characterized by the presence of Lewy bodies and Lewy neurites, which have abnormal aggregations of α-synuclein in the nigral and extranigral areas, including in the heart.
Eun Joo Chung, Sang Jin Kim
doaj   +1 more source

Assessment of genetic risk for improved clinical-neuropathological correlations

Acta Neuropathologica Communications, 2020
In the clinical diagnosis of dementia with Lewy bodies, distinction from Alzheimer’s disease is suboptimal and complicated by shared genetic risk factors and frequent co-pathology.
Barbara E. Spencer, Robin G. Jennings, Chun C. Fan, James B. Brewer   +3 more
doaj   +1 more source

Improving the diagnosis and management of Lewy body dementia: the DIAMOND-Lewy research programme including pilot cluster RCT

Programme Grants for Applied Research, 2021
Background: Lewy body dementia, comprising both dementia with Lewy bodies and Parkinson’s disease dementia, is the second commonest cause of neurodegenerative dementia.
John T O’Brien, John-Paul Taylor, Alan Thomas, Claire Bamford, Luke Vale, Sarah Hill, Louise Allan, Tracy Finch, Richard McNally, Louise Hayes, Ajenthan Surendranathan, Joseph Kane, Alexandros E Chrysos, Allison Bentley, Sally Barker, James Mason, David Burn, Ian McKeith   +17 more
doaj   +1 more source

Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies

Acta Neuropathologica Communications, 2020
Neurons of the nucleus basalis of Meynert (nbM) are vulnerable to Lewy body formation and neuronal loss, which is thought to underlie cognitive dysfunction in Lewy body dementia (LBD).
Christopher Hatton, Amy Reeve, Nichola Zoe Lax, Alasdair Blain, Yi Shiau Ng, Omar El-Agnaf, Johannes Attems, John-Paul Taylor, Doug Turnbull, Daniel Erskine   +9 more
doaj   +1 more source

Interaction between coxsackievirus B3 infection and α-synuclein in models of Parkinson's disease.

PLoS Pathogens, 2021
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. PD is pathologically characterized by the death of midbrain dopaminergic neurons and the accumulation of intracellular protein inclusions called Lewy bodies or Lewy neurites ...
Soo Jin Park, Uram Jin, Sang Myun Park
doaj   +2 more sources

Lewy body disease or diseases with Lewy bodies?

npj Parkinson's Disease, 2022
The current nosological concept of α-synucleinopathies characterized by the presence of Lewy bodies (LBs) includes Parkinson’s disease (PD), Parkinson’s disease dementia (PDD), and dementia with Lewy bodies (DLB), for which the term “Lewy body disease ...
Kateřina Menšíková, Radoslav Matěj, Carlo Colosimo, Raymond Rosales, Lucie Tučková, Jiří Ehrmann, Dominik Hraboš, Kristýna Kolaříková, Radek Vodička, Radek Vrtěl, Martin Procházka, Martin Nevrlý, Michaela Kaiserová, Sandra Kurčová, Pavel Otruba, Petr Kaňovský   +15 more
doaj   +1 more source

Neuropathology and molecular diagnosis of Synucleinopathies

Molecular Neurodegeneration, 2021
Synucleinopathies are clinically and pathologically heterogeneous disorders characterized by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies, Lewy neurites, neuronal cytoplasmic inclusions, and glial cytoplasmic ...
Shunsuke Koga, Hiroaki Sekiya, Naveen Kondru, Owen A. Ross, Dennis W. Dickson   +4 more
doaj   +1 more source