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The objective was to summarize recent findings about the clinical features, diagnosis and investigation of dementia with Lewy (DLB) bodies, together with its neuropathology, neurochemistry and genetics. Dementia with Lewy bodies (DLB) is a primary, neurodegenerative dementia sharing clinical and pathological characteristics with both Parkinson's ...
McKeith IG +10 more
+9 more sources
Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience [PDF]
Background: Dementia results from heterogeneous diseases of the brain. Mixed disease forms are increasingly recognized. Methods: We performed a survey within brain banks of BrainNet Europe to estimate the proportion of mixed disease forms underlying ...
Gelpi, Ellen +30 more
core +1 more source
Visual hallucinations in dementia with Lewy bodies: a transcranial magnetic stimulation study [PDF]
BACKGROUND: The aetiology of visual hallucinations is poorly understood in dementia with Lewy bodies. Pathological alterations in visual cortical excitability may be one contributory mechanism.
Livingstone, Anthea +17 more
core +2 more sources
Dementia Lewy Body (DLB) is a form of dementia characterized by abnormal accumulation of α-synuclein protein in the brain, forming lewy bodies that damage the function of neurons and nervous system.
Lubna Afina +4 more
doaj +1 more source
Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium
The Lewy Body Dementia Association (LBDA) held a virtual event, the LBDA Biofluid/Tissue Biomarker Symposium, on January 25, 2021, to present advances in biomarkers for Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLBs) and ...
Gregory D. Scott +54 more
doaj +1 more source
Advances in dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is a clinical diagnosis representing a specific presentation of a pathological α-synucleinopathy (Lewy body disease). DLB is one entity under the broader term Lewy body dementia , which also includes Parkinson’s disease ...
Melissa J. Armstrong
doaj +1 more source
Lewy body disease and dementia with Lewy bodies
In 1976 we reported our first autopsied case with diffuse Lewy body disease (DLBD), the term of which we proposed in 1984. We also proposed the term "Lewy body disease" (LBD) in 1980. Subsequently, we classified LBD into three types according to the distribution pattern of Lewy bodies: a brain stem type, a transitional type and a diffuse type.
openaire +3 more sources
Effects of α-synuclein on axonal transport
Lewy bodies and Lewy neurites composed primarily of α-synuclein characterize synucleinopathies including Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB).
Laura A. Volpicelli-Daley
doaj +1 more source
Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]
In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Goujet-Zalc Cécile +70 more
core +3 more sources
Common age‐related neuropathologies and yearly variability in cognition
Objective Cognitive variability is a potentially important source of heterogeneity in longitudinal cognitive profiles. We examined the extent to which common age‐related neuropathologies including Lewy bodies and Alzheimer’s disease (AD) contribute to ...
Lei Yu +6 more
doaj +1 more source

