Results 11 to 20 of about 43,190 (257)
Interaction between coxsackievirus B3 infection and α-synuclein in models of Parkinson's disease.
PLoS Pathogens, 2021 Parkinson's disease (PD) is one of the most common neurodegenerative diseases. PD is pathologically characterized by the death of midbrain dopaminergic neurons and the accumulation of intracellular protein inclusions called Lewy bodies or Lewy neurites ...
Soo Jin Park, Uram Jin, Sang Myun Park
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Lewy body disease or diseases with Lewy bodies?
npj Parkinson's Disease, 2022 The current nosological concept of α-synucleinopathies characterized by the presence of Lewy bodies (LBs) includes Parkinson’s disease (PD), Parkinson’s disease dementia (PDD), and dementia with Lewy bodies (DLB), for which the term “Lewy body disease ...
Kateřina Menšíková +15 more
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Dementia with Lewy bodies [PDF]
Clinical Medicine, 2019 Editor – Akintade and Pierres provide a useful review of the evaluation of cognitive impairment in their Acute Medical Care (AMC) report in July’s Clinical Medicine .[1][1] However, the patient described in their report does not have dementia with Lewy bodies (DLB).
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Proceedings of the National Academy of Sciences, 2006 Lewy bodies (LB) in the substantia nigra are a cardinal pathological feature of Parkinson's disease, but they occur in a number of neurodegenerative diseases and can be widespread in the nervous system. The characteristics, locations, and composition of LB are reviewed, with particular attention to α-synuclein (α-SYN), which appears to be the major ...
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Journal of Neurology, Neurosurgery & Psychiatry, 2001 James Parkinson noted: “A diseased state of the medulla spinalis, in that part which is contained in the canal, formed by the superior cervical vertebrae, and extending, as the disease proceeds, to the medulla oblongata . . .is the proximate cause.”1 In the late 19th century, because knowledge of the pathophysiology of the basal ganglia was imprecise,
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Archives of Neurology, 2003 The objective was to summarize recent findings about the clinical features, diagnosis and investigation of dementia with Lewy (DLB) bodies, together with its neuropathology, neurochemistry and genetics. Dementia with Lewy bodies (DLB) is a primary, neurodegenerative dementia sharing clinical and pathological characteristics with both Parkinson's ...
McKeith IG +10 more
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Neuropathology and molecular diagnosis of Synucleinopathies
Molecular Neurodegeneration, 2021 Synucleinopathies are clinically and pathologically heterogeneous disorders characterized by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies, Lewy neurites, neuronal cytoplasmic inclusions, and glial cytoplasmic ...
Shunsuke Koga +4 more
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A new visual rating scale for Ioflupane imaging in Lewy body disease
NeuroImage: Clinical, 2018 Background: Dopaminergic loss on 123I-Ioflupane brain imaging is a recognised biomarker for dementia with Lewy bodies. It is usually assessed using a visual rating scale developed for Parkinson's disease, which may not be optimal for dementia with Lewy ...
Jim J. Lloyd +7 more
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Gastrointestinal disorders in Parkinson’s disease and other Lewy body diseases
npj Parkinson's Disease, 2023 Parkinson’s disease (PD) is pathologically characterized by the abnormal accumulation of α-synuclein fibrils (Lewy bodies) in the substantia nigra and other brain regions, although the role of Lewy bodies remains elusive.
Masaaki Hirayama +3 more
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Journal of the Anus, Rectum and Colon, 2019 We systematically reviewed literature regarding "Lewy body constipation", i.e., constipation due to Lewy body diseases (LBD), with minimal neurologic symptoms. Epidemiology and pathology studies showed that LBD can start with constipation alone, mostly due to neuronal loss and appearance of Lewy bodies in the myenteric plexus. Because LBD significantly
Sakakibara, Ryuji +2 more
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