Results 51 to 60 of about 796,122 (288)

Differentiation Between Dementia With Lewy Bodies And Alzheimer’s Disease Using Voxel-Based Morphometry Of Structural MRI:AMulticenter Study

, 2019
Dementia with Lewy bodies (DLB) is one of the main etiologies of neurodegenerative dementia after Alzheimer’s disease (AD).1 Distinguishing DLB from AD is difficult because of their overlapping clinical and pathological features.2–4 Patients with ...
Asada, Takashi, Sato, Noriko, Ono, Tetsutaro, Yokoyama, Kota, Shigemori, Keiko, Mizumura, Sunao, 1001984, Hiroshi, Matsuda, 1001983, 1001986, Goto, Tomoaki, 1001985, 1001980, Nakatsuka, Tomoya, 1001982, 1001981, Matsuda, Hiroshi, Kanetaka, Hidekazu, 1001988, 1001987, Hanyu, Haruo, 1001989, Nemoto, Kiyotaka, Ito, Kengo, Terada, Hitoshi, 1001973, 1001972, 1001975, 1001974, Kawakatsu, Shinobu, 1001971, Hayashi, Hiroshi, 1001970, Shimada, Hitoshi, 1001977, 1001976, 1001979, 1001978, Suhara, Tetsuya, Oba, Hiroshi, Shinotoh, Hitoshi, Tetsuya, Suhara, 1001964, 1001969, 1001966, 1001965, 1001968, Hitoshi, Shinoto, 1001967, Hitoshi, Shimada, Kitamura, Shin   +50 more
core   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Lafora and Trétiakoff: the naming of the inclusion bodies discovered by Lewy

Arquivos de Neuro-Psiquiatria
Fritz Heinrich Jakob Lewy described, for the first time, in 1912, novel peculiar inclusions in neurons of certain brain nuclei in patients with Paralysis agitans, and compared his finding to the amyloid bodies described by Lafora one year before. Gonzalo
Eliasz Engelhardt
doaj   +1 more source

Prevalence of Submandibular Gland Synucleinopathy in Parkinson’s Disease, Dementia with Lewy Bodies and other Lewy Body Disorders

Journal of Parkinson’s Disease, 2016
Background: Clinical misdiagnosis, particularly at early disease stages, is a roadblock to finding new therapies for Lewy body disorders. Biopsy of a peripheral site might provide improved diagnostic accuracy.
Thomas G. Beach, Charles H. Adler, Geidy Serrano, Lucia I. Sue, D.G. Walker, Brittany N. Dugger, Holly A. Shill, Erika Driver-Dunckley, John N. Caviness, Anthony Intorcia, Jessica Filon, Sarah Scott, Angelica Garcia, Brittany Hoffman, Christine M. Belden, Kathryn J. Davis, Marwan N. Sabbagh,   +17 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Understanding the nature and impact of cognitive fluctuations and sleep disturbances in dementia with Lewy bodies: A qualitative caregiver study

SAGE Open Medicine
Objectives: Dementia with Lewy bodies is characterised by rapid fluctuations in attention, which are known as “cognitive fluctuations.” Despite the fact that cognitive fluctuations are considered to be a core dementia with Lewy bodies symptom, they are ...
Ellie Matterson, Gemma Wilson-Menzfeld, Kirsty Olsen, John-Paul Taylor, Greg J Elder   +4 more
doaj   +1 more source

Semantic memory is impaired in both dementia with Lewy Bodies (DLB) and dementia of Alzheimer's type (DAT): a comparative neuropsychological study and literature review [PDF]

, 2001
OBJECTIVE---To test the hypothesis that semantic impairment is present in both patients with dementia with Lewy bodies (DLB) and those with dementia of Alzheimer's type (DAT).
Whitworth, A.B., Garrard, P., Garrard, P, Powell, J., Hodges, J.R., Lambon Ralph, Matthew, Howard, D., Howard, D, Lambon Ralph, M.A., Hodges, J., Powell, J, Whitworth, A   +11 more
core  

How Do Lipids Localize in Lewy Bodies? [PDF]

, 2014
Lewy bodies are the pathological hallmark of Parkinson's disease (PD). While fibrillar α-synuclein (αS) is the main protein component of Lewy bodies, these structures also contain lipids.
Chaudhary, Himanshu, Subramaniam, Vinod, Claessens, Mireille M.A.E., Claessens, Mireille   +3 more
core   +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source

Neuropathological evidence of body-first vs. brain-first Lewy body disease

Neurobiology of Disease, 2021
Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB).
Per Borghammer, Jacob Horsager, Katrine Andersen, Nathalie Van Den Berge, Anna Raunio, Shigeo Murayama, Laura Parkkinen, Liisa Myllykangas   +7 more
doaj   +1 more source