Results 61 to 70 of about 796,122 (288)

Dementia With Lewy Bodies: A Review of Disease-Modifying Therapies for α-Synucleinopathies [PDF]

Aims: The global demographic transition has led to a growing ageing population. Neurodegenerative disease prevalence is high in the elderly, as aged brains accumulate molecular and cellular damage.
Bhattacharyya, Sharmi, Dar, Arzoo
core   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

LRRK2 in Parkinson's disease and dementia with Lewy bodies

Molecular Neurodegeneration, 2006
Background Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease (PD).
Zhu Xiongwei, Babar Asim, Siedlak Sandra L, Yang Qiwei, Ito Genta, Iwatsubo Takeshi, Smith Mark A, Perry George, Chen Shu G   +8 more
doaj   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Metabolic Correlates of Dopaminergic Loss in Dementia with Lewy bodies [PDF]

, 2020
BACKGROUND: Striatal dopamine deficiency and metabolic changes are well-known phenomena in dementia with Lewy bodies and can be quantified in vivo by 123 I-Ioflupane brain single-photon emission computed tomography of dopamine transporter and 18 F ...
Buerger, Katharina,, Leonie Beyer, Aarsland, Dag,, Ochoa-Figueroa, Miguel A, Boris‐Stephan Rauchmann, Kramberger, Milica G, Nicastro, Nicolas,, Robert Perneczky, Pardini, Matteo,, Pogarell, Oliver, Maria Huber, Nicolas Nicastro, Prix, Catharina, Garcia-Ptacek, Sara,, Huber, Maria, Ochoa-Figueroa, Miguel A., Valle Camacho, Frisoni, Giovanni B.,, Chincarini, Andrea,, Vandenberghe, Rik,, Pogarell, Oliver,, Kramberger, Milica G., Lemstra, Afina W., Valentina Garibotto, Adrian Danek, Rose Bruffaerts, Rik Vandenberghe, Unterrainer, Marcus, Sambuceti, Gianmario, Levin, Johannes, Enrico Peira, Nicastro, Nicolas, Davidsson, Anette, Cihan Catak, Lemstra, Afina W.,, Schnabel, Jonas,, Beyer, Leonie, Garibotto, Valentina, Milica G. Kramberger, Katharina Buerger, Cumming, Paul,, Garibotto, Valentina,, Sambuceti, Gianmario,, Peira, Enrico, Camacho, Valle,, Arnaldi, Dario,, Jonathan Vöglein, Axel Rominger, Vandenberghe, Rik, Ewers, Michael,, Silvia Morbelli, Andrea Pilotto, Flavio Nobili, Morbelli, Silvia, Davidsson, Anette,, Grmek, Marko, Lemstra, Afina, Bauckneht, Matteo,, Rominger, Axel,, Schönecker, Sonja, Pilotto, Andrea,, Schnabel, Jonas, Alessandro Padovani, Cumming, Paul, Pardini, Matteo, Voeglein, Jonathan,, Peira, Enrico,, Rominger, Axel, Andrea Chincarini, Levin, Johannes,, Brendel, Matthias, Savitcheva, Irina, Perneczky, Robert, Zande, Jessica, Padovani, Alessandro, Matthias Brendel, Trost, Maja, Oliver Pogarell, Bruffaerts, Rose, Sonja Schönecker, Ochoa‐Figueroa, Miguel A., Grmek, Marko,, Peter Bartenstein, Van Laere, Koen, Carla Palleis, Gianmario Sambuceti, Catak, Cihan, Frisoni, Giovanni B, Irina Savitcheva, Savitcheva, Irina,, Ochoa-Figueroa, Miguel, Bauckneht, Matteo, Frisoni, Giovanni, Unterrainer, Marcus,, Chincarini, Andrea, Camacho, Valle, Palleis, Carla, Dag Aarsland, Lemstra, Evelien, Giovanni B. Frisoni, Matteo Pardini, Lemstra, Afina W, Beyer, Leonie,, van der Zande, Jessica, Schoenecker, Sonja,, Koen Van Laere, Nobili, Flavio, Matteo Bauckneht, Morbelli, Silvia,, Danek, Adrian, Padovani, Alessandro,, Garcia-Ptacek, Sara, Aarsland, Dag, Laere, Koen van, Frisoni, Giovanni B., Van Laere, Koen,, Catharina Prix, Bruffaerts, Rose,, Ewers, Michael, Marko Grmek, Miguel A. Ochoa‐Figueroa, Kramberger, Milica G.,, Brendel, Matthias,, Palleis, Carla,, Ochoa-Figueroa, Miguel A.,, Prix, Catharina,, Huber, Maria,, Johannes Levin, Perneczky, Robert,, Marcus Unterrainer, Buerger, Katharina, Nobili, Flavio,, Zande, Jessica van der, Arnaldi, Dario, Vöglein, Jonathan, Jonas Schnabel, Maja Trost, Afina W. Lemstra, Jessica van der Zande, Bartenstein, Peter,, Rauchmann, Boris‐Stephan, van der Zande, Jessica,, Catak, Cihan,, Trost, Maja,, Paul Cumming, Michael Ewers, Pilotto, Andrea, Danek, Adrian,, Sara Garcia‐Ptacek, Garcia‐Ptacek, Sara, Rauchmann, Boris-Stephan, Dario Arnaldi, Schoenecker, Sonja, Kramberger, Milica, Voeglein, Jonathan, Anette Davidsson, Universitat Autònoma de Barcelona, Rauchmann, Boris-Stephan,, Bartenstein, Peter   +158 more
core   +2 more sources

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Dementia with Lewy Bodies.

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2000
Dementia with Lewy bodies (DLB), the second most frequent cause of primary degenerative dementias following Alzheimer's disease, has been increasingly recognized since the proposal of the consensus name and clinical diagnostic criteria. Although DLB overlaps in clinical, pathological, and genetic features with Alzheimer's disease and Parkinson's ...
openaire   +3 more sources

Young-Onset Dementia with Lewy Bodies

Case Reports in Neurology, 2018
Young-onset (< 65 years) dementia is a challenging clinical problem. A 61-year-old man visited our clinic because of a 2-year history of mild cognitive impairment of the executive disorder type.
Yosuke Aiba, Ryuji Sakakibara, Tsuyoshi Ogata, Ayako Iimura, Keiichiro Terayama, Keiko Suzuki, Shuichi Katsuragawa, Yuuki Kato, Fuyuki Tateno, Hitoshi Terada, Tsutomu Inaoka, Tomoya Nakatsuka   +11 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Frederic Lewy: how the two World Wars changed his life, work, and name

Arquivos de Neuro-Psiquiatria
In 1912, Friedrich Lewy described the inclusion bodies present in Parkinson disease and in Lewy body dementia. Throughout his life, Lewy fought in two wars – on opposite sides.
Patrick Emanuell Mesquita Sousa-Santos, Pedro Machry Pozzobon, Igor de Lima e Teixeira   +2 more
doaj   +1 more source