Results 71 to 80 of about 43,463 (255)

Is Cell Death Primary or Secondary in the Pathophysiology of Idiopathic Parkinson’s Disease?

Biomolecules, 2015
Currently, the pathophysiology of idiopathic Parkinson’s disease is explained by a loss of mainly dopaminergic nerve cells that causes a neurotransmitter deficiency.
Walter J. Schulz-Schaeffer
doaj   +1 more source

Blood Biomarkers of Alzheimer's Disease and Patterns of Structural Brain Changes in the Community

Annals of Neurology, EarlyView.
Objective We aimed to investigate the associations between Alzheimer's disease (AD)‐related blood biomarkers and changes in brain volumes and cerebrovascular burden in community‐dwelling older adults. Methods We included 361 dementia‐free participants with a Mini‐Mental State Examination (MMSE) score ≥ 27 and without prior cerebrovascular events from a
Martina Valletta, Davide Liborio Vetrano, Erika J. Laukka, Grégoria Kalpouzos, Javier Oltra, Debora Rizzuto, Marco Canevelli, Claudia Fredolini, Chengxuan Qiu, Bengt Winblad, Laura Fratiglioni, Giulia Grande   +11 more
wiley   +1 more source

Lewy Body Dementias [PDF]

Continuum, 2016
This article provides an overview of the clinical features, neuropathologic findings, diagnostic criteria, and management of dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD), together known as the Lewy body dementias.DLB and PDD are common, clinically similar syndromes that share characteristic neuropathologic changes, including ...
openaire   +2 more sources

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Prediction of Co-Occurrence of Lewy Body Disease with Alzheimer’s Disease

Journal of Alzheimer's Disease Reports
Identifying the coexistence of Lewy body (LB) pathology with Alzheimer’s disease (AD) in clinical practice is important in the era of anti-amyloid-β antibody therapy. However, few studies have predicted the presence of comorbid LB pathology with AD using
Kenichi Hashiguchi, Ryota Kobayashi, Daichi Morioka, Shinobu Kawakatsu, Kazutaka Sakamoto, Hiroshi Matsuda, Akihito Suzuki   +6 more
doaj   +1 more source

Parkinson's Disease

MedEdPORTAL, 2012
Parkinson's disease is a degenerative disorder of the central nervous system resulting from the death of dopamine producing cells in the substantia nigra.
Douglas Gould, Lisa Haubert
doaj   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Vocal Fold Atrophy in Patients With Alzheimer's Disease and Related Dementias

The Laryngoscope, EarlyView.
This is the first study to quantify vocal fold atrophy in patients with Alzheimer's disease and related dementias (AD/ADRD) using endoscopic imaging. Compared with age‐matched controls, AD/ADRD patients showed significantly greater vocal fold bowing and reduced mucosal wave amplitude, while normalized glottal gap area did not differ.
Byron Kim, Carson Miller, Shruti Dhingra, Mahdi Al‐Ghezi, Emily Wilson, Neel K. Bhatt   +5 more
wiley   +1 more source

Lewy and his inclusion bodies: Discovery and rejection

Dementia & Neuropsychologia
Fritz Jacob Heinrich Lewy described the pathology of Paralysis agitans [Parkinson disease] and was the first to identify eosinophilic inclusion bodies in neurons of certain brain nuclei, later known as Lewy bodies, the pathological signature of the Lewy ...
Eliasz Engelhardt, Marleide da Mota Gomes   +1 more
doaj   +1 more source

Explicit Dynamics Analysis of the Impact Response of Lithium‐Ion Cells

Macromolecular Symposia, EarlyView.
ABSTRACT It is very important to make sure that EV lithium‐ion cells are safe when they are abused, like when they are hit or crushed. This kind of loading can cause structural failure or thermal runaway. Even though FEA is used a lot, common practices make the jellyroll the same and ignore the fact that the electrolyte is a moving fluid.
Radu‐Ionuț Stoica, Emanuel‐Eduard Zencenco, Gabriel‐Dumitru Smaranda   +2 more
wiley   +1 more source