Results 11 to 20 of about 726 (147)

"Real-world" eligibility for anti-amyloid treatment in a tertiary memory clinic setting. [PDF]

Alzheimers Dement
Abstract INTRODUCTION The societal impact of anti‐amyloid treatment (AAT) for Alzheimer's disease (AD) depends largely on patient eligibility. Estimates suggest that 1% to 18% of individuals with AD may qualify for AAT; however, data from everyday clinical practice remain limited.
Vigneswaran S, Vijverberg EGB, Barkhof F, van de Giessen E, Lemstra AW, Pijnenburg Y, Teunissen CE, van der Flier WM, van Harten AC.   +8 more
europepmc   +2 more sources

Structural and functional connectivity in tau mutation carriers: from presymptomatic to symptomatic frontotemporal dementia. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Microtubule‐associated protein tau (MAPT) mutations cause frontotemporal dementia (FTD), characterised by behavioural, language, and motor impairments due to brain connectivity disruptions. We investigated structural and functional connectivity in 86 mutation carriers and 272 controls to map connectivity changes at different ...
Bouzigues A, Du VL, Joulot M, Peysson N, Houot M, Béranger B, Russell LL, Foster PH, Ferry-Bolder E, van Swieten JC, Jiskoot L, Seelaar H, Sanchez-Valle R, Laforce R, Graff C, Galimberti D, Vandenberghe R, de Mendonça A, Tiraboschi P, Santana I, Gerhard A, Levin J, Sorbi S, Otto M, Bertoux M, Lebouvier T, Ducharme S, Butler CR, Ber IL, Finger E, Tartaglia MC, Masellis M, Rowe JB, Synofzik M, Moreno F, Borroni B, Rohrer JD, Migliaccio R, GENetic Frontotemporal dementia Initiative (GENFI).   +38 more
europepmc   +2 more sources

Cross-country variance in facial emotion recognition in presymptomatic and symptomatic behavioral variant frontotemporal dementia: Insights from the GENFI and ReDLat consortia. [PDF]

Alzheimers Dement
Abstract INTRODUCTION We investigated international differences in facial emotion recognition (FER) across stages of frontotemporal dementia (FTD). Previous studies may have missed early decline by combining data and masking variations in FER across countries.
de Boer L, Jiskoot LC, Seelaar H, van Swieten JC, Ibanez A, Maito M, Fittipaldi S, De Houwer JFH, Swartenbroekx T, Boesjes PA, Convery RS, Ferry-Bolder E, Foster P, Bouzigues A, Chisman-Russell L, van den Berg E, Papma J, Franzen S, Bourdage R, Rowe JB, Borroni B, Galimberti D, Tiraboschi P, Masellis M, Finger E, Laforce R, Graff C, Gerhard A, Sanchez-Valle R, Mendonça A, Moreno F, Synofzik M, Vandenberghe R, Ducharme S, Le Ber I, Levin J, Lebouvier T, Nacmias B, Otto M, Butler CR, Santana I, Bertoux M, Tartaglia MC, Rohrer JD, Poos JM, GENFI Consortium.   +45 more
europepmc   +2 more sources

Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Higher male prevalence in sporadic behavioral variant frontotemporal dementia (bvFTD) has been reported. We hypothesized differences in phenotypes between genetic and sporadic bvFTD females resulting in underdiagnosis of sporadic bvFTD females.
Liu X, de Boer SCM, Cortez K, Poos JM, Illán-Gala I, Heuer H, Forsberg LK, Casaletto K, Memel M, Appleby BS, Barmada S, Bozoki A, Clark D, Cobigo Y, Darby R, Dickerson BC, Domoto-Reilly K, Galasko DR, Geschwind DH, Ghoshal N, Graff-Radford NR, Grant IM, Hsiung GR, Honig LS, Huey ED, Irwin D, Kantarci K, Léger GC, Litvan I, Mackenzie IR, Masdeu JC, Mendez MF, Onyike CU, Pascual B, Pressman P, Bayram E, Ramos EM, Roberson ED, Rogalski E, Bouzigues A, Russell LL, Foster PH, Ferry-Bolder E, Masellis M, van Swieten J, Jiskoot L, Seelaar H, Sanchez-Valle R, Laforce R, Graff C, Galimberti D, Vandenberghe R, de Mendonça A, Tiraboschi P, Santana I, Gerhard A, Levin J, Sorbi S, Otto M, Pasquier F, Ducharme S, Butler CR, Ber IL, Finger E, Rowe JB, Synofzik M, Moreno F, Borroni B, Boeve BF, Boxer AL, Rosen HJ, Pijnenburg YAL, Rohrer JD, Tartaglia MC, ALLFTD Consortium and the GENFI Consortium.   +74 more
europepmc   +2 more sources

Distinctive cell-free DNA methylation characterizes presymptomatic genetic frontotemporal dementia. [PDF]

Ann Clin Transl Neurol
Abstract Objective Methylation of plasma cell‐free DNA (cfDNA) has potential as a marker of brain damage in neurodegenerative diseases such as frontotemporal dementia (FTD). Here, we study methylation of cfDNA in presymptomatic and symptomatic carriers of genetic FTD pathogenic variants, next to healthy controls.
Giannini LAA, Boers RG, van der Ende EL, Poos JM, Jiskoot LC, Boers JB, van IJcken WFJ, Dopper EG, Pijnenburg YAL, Seelaar H, Meeter LH, van Rooij JGJ, Scheper W, Gribnau J, van Swieten JC.   +14 more
europepmc   +2 more sources

Biomarkers of endothelial dysfunction and cognition: A two-step IPD meta-analysis. [PDF]

Alzheimers Dement
Abstract INTRODUCTION This study assessed the association of plasma biomarkers of endothelial dysfunction with cognitive performance and decline. METHODS Data from 9414 individuals from eight Dutch cohorts were included (Ø age‐range: 57–93 years). Plasma biomarkers of endothelial dysfunction (soluble intercellular adhesion molecule‐1 (sICAM‐1), soluble
Beran M, Jansen WJ, Oomens JE, Moonen JEF, Slagboom PE, Huisman M, Kok AAL, Nooyens ACJ, Verschuren WMM, Stehouwer CDA, Schalkwijk C, Köhler S, Beekman M, Slagboom PE, Wolters FJ, Ikram MA, Vallerga CL, van Meurs JBJ, Ghanbari M, Vonk JMJ, Geerlings MI, van Sloten TT, Schram MT, NCDC Consortium.   +23 more
europepmc   +2 more sources

Contributions of amyloid beta and cerebral small vessel disease in clinical decline. [PDF]

Alzheimers Dement
Abstract INTRODUCTION We assessed whether co‐morbid small vessel disease (SVD) has clinical predictive value in preclinical or prodromal Alzheimer's disease. METHODS In 1090 non‐demented participants (65.4 ± 10.7 years) SVD was assessed with magnetic resonance imaging and amyloid beta (Aβ) with lumbar puncture and/or positron emission tomography scan ...
Moonen JEF, Haan R, Bos I, Teunissen C, van de Giessen E, Tomassen J, den Braber A, van der Landen SM, de Geus EJC, Legdeur N, van Harten AC, Trieu C, de Boer C, Kroeze L, Barkhof F, Visser PJ, van der Flier WM.   +16 more
europepmc   +2 more sources

Kwaliteit van leven bij dementie

Tijdschrift voor Gerontologie en Geriatrie, 2010
In de literatuur worden verschillende definities van ‘kwaliteit van leven’ gevonden. Dit roept de vraag op welke domeinen als belangrijk worden gezien door mensen met dementie zelf.
D. L. Gerritsen, R. M. Dröes, T. P. Ettema, E. Boelens, J. Bos, L. Meihuizen, J. de Lange, C. J. M. Schölzel-Dorenbos, F. Hoogeveen   +8 more
doaj   +1 more source

De Amsterdamse Dementie-Screeningstest (ADS) bij ouderen zonder neurocognitieve stoornis. Implicaties voor de klinische praktijk

Tijdschrift voor Gerontologie en Geriatrie, 2016
De Amsterdamse Dementie-Screeningstest (ADS) bestaat uit zes subtests voor onderzoek van leren en geheugen (Visueel geheugen, Oriëntatie, Achtwoordentest), executieve functies (Meander), taal (Fluency) en visueel-constructievermogen (Natekenen).
Meta van Toutert, Han F.A. Han Diesfeldt, Dirk Hoek   +2 more
doaj   +1 more source

Bruikbaarheid en validiteit van de Nederlandse versie van de Montreal Cognitive Assessment (MoCA-D) bij het diagnosticeren van Mild Cognitive Impairment

Tijdschrift voor Gerontologie en Geriatrie, 2010
Doel: De MoCA is een nieuwe screeningstest voor Mild Cognitive Impairment (MCI). Doel van dit onderzoek is validering van de Nederlandse versie (MoCA-D). Methode: De MoCA-D werd afgenomen bij gezonde ouderen en patiënten met MCI of dementie afkomstig
A. J. A. M. Thissen, F. van Bergen, J. F. M. de Jonghe, R. P. C. Kessels, P. L. J. Dautzenberg   +4 more
doaj   +1 more source