Results 121 to 130 of about 61,222 (298)
A visão dos conceitos de Informação e Tecnologia à luz da Engenharia Organizacional
Ciência da Informação, 2015 Apresenta o campo da engenharia organizacional, bem como o método DEMO de desenho e engenharia para organizações (do inglês: Design and Engineering Methodology for Organizations – DEMO) e como se pode perspectivar de maneira menos ambígua os conceitos de
David Sardinha Andrade de Aveiro
doaj
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
Demo video of Schrödinger\u27s box: "solid 2" [PDF]
Demo video of Schrödinger\u27s box: "solid ...
Weger, Marian (University of Music and Performing Arts Graz, Austria)
core
Uno sguardo d'insieme: il Veneto del rinascimento (1509-1630) [PDF]
, 2016 Il saggio costituisce sia una sintesi complessiva delle problematiche affrontate nell'intero volume, sia un'interpretazione originale dei principali fenomeni storici, culturali e storico-architettonici relativi al territorio della Repubblica di Venezia ...
Walter Panciera +7 more
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Demo video of Schrödinger\u27s box: "big metal thing" [PDF]
Demo video of Schrödinger\u27s box: "big metal ...
Weger, Marian (University of Music and Performing Arts Graz, Austria)
core