Results 71 to 80 of about 570,556 (295)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Senescence vs. sustenance: evolutionary-demographic models of aging [PDF]

open access: yes
Humans, and many other species, suffer senescence: mortality increases and fertility declines with adult age. Some species, however, enjoy sustenance: mortality and fertility remain constant.
Annette Baudisch, James W. Vaupel
core   +3 more sources

Demografik Yaşlanma ve Yaşlılara Yönelik Kamusal Hizmetlerin İncelenmesi: İzmir İli Örneği

open access: yesJournal of Literature and Humanities
Demografik yaşlanma dünyada ve ülkemizde giderek belirgin bir sorun haline gelmektedir. Artan yaşlı nüfusun beraberinde getirdiği sosyal ve ekonomik sorunlara karşı küresel ve ulusal çapta çözüm arayışları sürmektedir.
Fatih Ayhan, Zeliha Kantik
doaj   +1 more source

Calidad de vida y condiciones de salud de la población adulta mayor de Medellín.

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2006
Introducción. El proceso de envejecimiento presenta limitaciones funcionales, pérdida de autonomía y de independencia, de adaptabilidad y disfuncionalidad motriz, las cuales plantean retos y preocupaciones de vital importancia tanto para quienes las ...
Doris Cardona   +2 more
doaj   +1 more source

Macroeconomic and policy implications of population aging in Brazil [PDF]

open access: yes
This paper analyzes the macroeconomic implications of population aging in Brazil. Three alternative yet complementary methodologies are adopted, and depending on policy responses to the fiscal implications of aging, there are two main findings: First ...
Jorgensen, Ole Hagen
core  

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

open access: yesAging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath   +3 more
wiley   +1 more source

Contemporary population and development challenges in the Municipality of Dubrovačko Primorje, Croatia

open access: yesGeoadria, 2010
The purpose of this paper is to define the basic issues and opportunities challenging the modern development of the Municipality of Dubrovačko Primorje, their causes and effects.
Helena Karlić Mujo
doaj  

Aging, pension reform, and capital flows: A multi-country simulation model [PDF]

open access: yes
In this paper, we present a quantitative analysis of the international capital flows induced by differences in population aging processes across countries and by pension reforms.
Börsch-Supan, Axel   +2 more
core  

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha   +4 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

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