Results 61 to 70 of about 7,447,288 (307)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Northland Region and its territorial authorities: Demographic profile 1986-2031 [PDF]

, 2014
This report outlines the demographic changes that have occurred in the Northland Region, as well as what trends are expected in the ...
Jackson, Natalie
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Added value from European Territorial Co-operation: the impact of demographic change in the Alps on the young

Bulletin of Geography. Socio-Economic Series, 2015
The article sets demographic change in the Alps in the framework of European Territorial Cooperation programs. A statistical overview of selected regions in five Alpine countries serves as a basis for further policy analysis. The latter was undertaken to
Marot Naja, Gantar Damjana, Mali Barbara Černič   +2 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The future size of religiously affiliated and unaffiliated populations

Demographic Research, 2015
Background: People who are religiously unaffiliated (including self-identifying atheists and agnostics, as well as those who say their religion is "nothing in particular") made up 16.4Š of the world's population in 2010.
Conrad Hackett, Marcin Stonawski, Michaela Potančoková, Brian J. Grim, Vegard Skirbekk   +4 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Demographic Trends and Regional Disparities in the EU

Social Sciences
This paper investigates the impact of demographic changes on regional disparities within the European Union. The analysis focuses on key demographic trends—population ageing, low fertility rates, and migration flows—and their long-term implications for ...
Ana Milijić, Aleksandar Manasijević, Dejan Đorđević, Vladislav Marjanović, Marina Stanojević   +4 more
doaj   +1 more source

Auckland Region - Socio-Demographic Profile 1986-2031 [PDF]

, 2012
This report outlines the socio-demographic changes that have occurred in Auckland, as well as what trends are expected in the ...
Jackson, Natalie
core