Results 71 to 80 of about 7,447,288 (307)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Demographic Change and Economic Growth in Asia [PDF]

In 1994 the World Bank called East Asia's strong economic growth performance a "miracle". Trade openness, high savings rates, human capital accumulation, and macroeconomic policy only explained part of this growth performance; the remainder was left ...
David E. Bloom, Jocelyn E. Finlay, David Canning   +2 more
core  

Thinking about post-transitional demographic regimes : a reflection [PDF]

, 2013
BACKGROUND: For the last 70 years the concept of the demographic transition has provided a basis for understanding and predicting population trends in the developing world.
Wilson, Christopher Cleveland Boag
core   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

How Well Can the Migration Component of Regional Population Change be Predicted? A Machine Learning Approach Applied to German Municipalities

Comparative Population Studies, 2020
For several decades, demographic forecasts had predicted that the majority of Germany’s cities and rural areas would experience population decline in the early 21st century. Instead, recent trends show a growing population size in three out of every four
Hannes Weber
doaj  

Inner-City Transformations after Socialism. Findings from Interviews with New Residents of Pre-War Tenement Houses in Gdańsk

Bulletin of Geography. Socio-Economic Series, 2011
Issues of intense suburbanization and urban sprawl have been the most discussed threads in the recent debate on urban development in Poland. Meanwhile, in numerous cities of Western Europe signs of inner-city revival have been observed and ...
Maja Grabkowska
doaj   +1 more source

Chronological objects in demographic research [PDF]

, 2013
Background: Calendar time, age and duration are chronological objects. They represent an instant or a time period. Age and duration are usually expressed in units with varying lengths.
Willekens, F.J.C., Frans J. Willekens
core   +4 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source