Results 211 to 220 of about 115,066 (306)

Network analysis of school connectedness and psychological crisis among university students. [PDF]

BMC Psychol
Zhang D, Gao N, Wang Y, Liu X, Peng H, Hu S, Liu X.   +6 more
europepmc   +1 more source

The demographic crisis in Europe: implications and reflections

, 2007
This paper first examines how all European countries have converged towards low fertility leading to a "demographic winter" and aging "from the bottom". Then the geography of fertility in Europe is studied, to highlight the disparities in the rhythm of the evolution of the fertility.
openaire   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Impact of the economic crisis on general health-seeking behavior and chronic disease management: a comparative study of public perceptions in the Western and Uva Provinces of Sri Lanka. [PDF]

BMC Health Serv Res
Nilaweera AI, Fernando DR, Adikaranayake PR, Perera AN, Dakshina T, Weerakoon S, Wijayathilaka N, Nethmini T, Jayalath D, Hettiarachchi D, Indrawansa S, Dissanayake H, Wijayaratne DR, Katulanda P.   +13 more
europepmc   +1 more source

Demographic opportunity window to be transform to demographic crisis window for Turkey?

, 2019
Burhan Can, Sedat Avcı
openaire   +2 more sources

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Mapping the digital determinants of health: a machine learning analysis of YouTube narratives on child undernutrition in Pakistan. [PDF]

J Glob Health
Shahid M, Song J, Ali Z, Naveed HM, Yuksel S, Dincer H.   +5 more
europepmc   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Geographic Disparities in Oral Health Among Schoolchildren in Damascus, Syria, During the Prolonged Crisis: A Cross-Sectional Study. [PDF]

Cureus
Ashour A, Dashash M.
europepmc   +1 more source