Results 41 to 50 of about 591,496 (306)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

The initial journey of an Endangered penguin: implications for seabird conservation

Endangered Species Research, 2013
Seabirds can disperse widely in search of prey, especially during non-breeding periods. Conservation measures predominately focus on protecting breeding colonies, but juvenile survival and recruitment can have critical impacts on population dynamics.
RB Sherley, K Ludynia, T Lamont, JP Roux, RJM Crawford, LG Underhill   +5 more
doaj   +1 more source

Prevalence and determinants of unmet need for contraception among women in low and high-priority segments for family planning demand generation in Nigeria

Archives of Public Health, 2022
Plain Language Summary Existing studies have identified diverse predictors of unmet need for contraception. These predictors cut across individual, household, community, and health facility levels.
Bola Lukman Solanke, Olufemi Mayowa Adetutu, Semiu Adebayo Rahman, Daniel Alabi Soladoye, Michael Olumide Owoeye   +4 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Factors Affecting Attitudes towards Cohabitation among Iranian Youth [PDF]

جامعه شناسی کاربردی
Introduction In previous decades, marriage has been more prevalent, while cohabitation has been largely limited to specific social groups. However, attitudes toward cohabitation are shifting in many countries, resulting in its increased acceptance and ...
Reyhane Ghasemi Neyasar, Rasoul Sadeghi, Fatemeh Torabi   +2 more
doaj   +1 more source

How to measure multidimensional quality of life of persons with disabilities in public policies - a case of Poland

Archives of Public Health, 2022
Background The aim of this paper is to construct a tool that can be used to measure multidimensional quality of life of persons with disabilities in comparison with population without disabilities for the purpose of monitoring of the UN Convention on the
Izabela Grabowska, Radosław Antczak, Jan Zwierzchowski, Tomasz Panek   +3 more
doaj   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

“I Thought It Would Have Been More about Only the Fun Stuff”—Exploring the Expectation–Reality Gap among the Novice Solo Self-Employed

Businesses, 2023
Research on the career expectations of employees and the potential (mis)match with their lived reality is abundant, yet the research field has paid less attention to the expectation–reality gap of the self-employed.
Jessie Gevaert, Kim Bosmans, Deborah De Moortel, Christophe Vanroelen   +3 more
doaj   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Demography Is Not Destiny, Revisited [PDF]

, 2005
Looks at the impending demographic challenges of the aging American population. Considers the impact of factors in addition to anticipated changes in the size and age distribution, particularly those related to the economy and public ...
Laura Summer, Robert B. Friedland
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