Results 41 to 50 of about 1,824,687 (352)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

The initial journey of an Endangered penguin: implications for seabird conservation

Endangered Species Research, 2013
Seabirds can disperse widely in search of prey, especially during non-breeding periods. Conservation measures predominately focus on protecting breeding colonies, but juvenile survival and recruitment can have critical impacts on population dynamics.
RB Sherley, K Ludynia, T Lamont, JP Roux, RJM Crawford, LG Underhill   +5 more
doaj   +1 more source

Demography Is Not Destiny [PDF]

, 1999
Examines demographic and economic trends, and other challenges and opportunities associated with the aging American population. Highlights the interactions that occur among public programs, private institutions, and individuals.
Laura Summer, Robert B. Friedland
core  

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Molecular characterization of rotavirus group A strains circulating prior to vaccine introduction in rural coastal Kenya, 2002-2013 [version 2; peer review: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2019
Background: Kenya introduced the monovalent Rotarix® rotavirus group A (RVA) vaccine nationally in mid-2014.  Long-term surveillance data is important prior to wide-scale vaccine use to assess the impact on disease and to investigate the occurrence of ...
Betty E. Owor, Mike J. Mwanga, Regina Njeru, Robert Mugo, Mwanajuma Ngama, Grieven P. Otieno, D.J. Nokes, C.N. Agoti   +7 more
doaj   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Qualitative research about public health risk perceptions on ambient air pollution. A review study

SSM: Population Health, 2021
Background: Understanding public health risk perceptions is essential in efficient environmental health management. In the light of the negative impact of air pollution on health and the direct and indirect mediation of this impact through risk ...
Charlotte Noël, Christophe Vanroelen, Sylvie Gadeyne   +2 more
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Factors Affecting Attitudes towards Cohabitation among Iranian Youth [PDF]

جامعه شناسی کاربردی
Introduction In previous decades, marriage has been more prevalent, while cohabitation has been largely limited to specific social groups. However, attitudes toward cohabitation are shifting in many countries, resulting in its increased acceptance and ...
Reyhane Ghasemi Neyasar, Rasoul Sadeghi, Fatemeh Torabi   +2 more
doaj   +1 more source

“I Thought It Would Have Been More about Only the Fun Stuff”—Exploring the Expectation–Reality Gap among the Novice Solo Self-Employed

Businesses, 2023
Research on the career expectations of employees and the potential (mis)match with their lived reality is abundant, yet the research field has paid less attention to the expectation–reality gap of the self-employed.
Jessie Gevaert, Kim Bosmans, Deborah De Moortel, Christophe Vanroelen   +3 more
doaj   +1 more source