Results 61 to 70 of about 665,429 (358)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Demography and the environment [PDF]

open access: yesDemography, 1998
AbstractDemographers' interest in the environment has generally been enmeshed in broader issues of population growth and economic development. Empirical research by demographers on environmental issues other than natural-resource constraints is limited.
openaire   +3 more sources

Microbial metabolism: optimal control of uptake versus synthesis [PDF]

open access: yes, 2014
Microbes require several complex organic molecules for growth. A species may obtain a required factor by taking up molecules released by other species or by synthesizing the molecule.
Frank, Steven A.
core   +3 more sources

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

open access: yesFEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu   +6 more
wiley   +1 more source

Disciplining anthropological demography [PDF]

open access: yes
This study furthers the epistemological development of anthropological demography, and its role in understanding the demography of Europe. Firstly we situate anthropological demography against the context of an evolving world of research in which ...
Ernestina Coast   +2 more
core  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

The Duration of Couples\' Childlessness: An Analysis of Differences and Determinants [PDF]

open access: yesمجله دانشگاه علوم پزشکی گرگان, 2023
Maryam Alimoradian , Hajiieh Bibi Razeghi Nasrabad *  , Maliheh Alimondegari , Abbas Askari-Nodoushan  Background and Objective: A basic factor in the reduction of fertility levels is delayed fertility.
Maryam Alimoradian   +3 more
doaj  

Card games are effective tools to enhance foundation year health and safety inductions

open access: yesFEBS Open Bio, EarlyView.
A series of three card games was developed to actively deliver health and safety education to foundation year students. Most students reported positive responses regarding their enjoyment (89.9 %) and learning (74.7 %) from all games evaluated. Data revealed significant improvements in health and safety knowledge (P < 0.0001).
Rumana Rafiq   +4 more
wiley   +1 more source

On the Demography of Aging [PDF]

open access: yesDemography, 1980
This paper is concerned with the contributions of demography to gerontology or the demography of aging. The major interests of gerontological demographers and outstanding issues and problems are discussed in terms of the process of aging. Problems of definition of old age and aging are noted in terms of: 1) the lack of a universally acceptable ...
openaire   +3 more sources

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