Results 71 to 80 of about 327,986 (310)
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Institutional mechanisms for a model of effective family-demographic policy
RUDN journal of SociologyMaintaining demographic potential is one of the basic components of national demographic security. To achieve this goal, the state should solve many tasks among which the most relevant are strengthening the family, increasing the birth rate and ...
T. K. Rostovskaya +2 more
doaj +1 more source
Causal assessment in demographic research
Genus, 2020 Causation underlies both research and policy interventions. Causal inference in demography is however far from easy, and few causal claims are probably sustainable in this field. This paper targets the assessment of causality in demographic research.
Guillaume Wunsch, Catherine Gourbin
doaj +1 more source
Human Evolutionary Demography: Introduction and Rationale
Human evolutionary demography combines research in evolutionary biology with the study of human demographic patterns and behaviors. Evolutionary biology and demography share many conceptual features that give rise to a natural complementarity, such as a ...
Sear, R, Lee, R, Burger, O
core +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
Wellcome Open ResearchBackground Human metapneumovirus (hMPV) is a major contributor of acute respiratory infections (ARI) in childhood and vulnerable adults. It comprises two antigenically distinct lineages (A and B), with multiple sub-lineages.
Martin Mutunga +8 more
doaj +1 more source
Aging and Cancer, EarlyView.This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
Sources for an Australian Interdisciplinary Historical Demography
, 2019 This chapter begins with quantitative sources: population censuses, vital registration, administrative statistics (including convict records), and sample surveys. This is followed by a short section on the many qualitative sources and a discussion of the
Kippen, Rebecca, Lucas, David
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source