Results 151 to 160 of about 191,388 (295)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Imitation Learning from Purified Demonstrations [PDF]

Imitation learning has emerged as a promising approach for addressing sequential decision-making problems, with the assumption that expert demonstrations are optimal.
Wang, Yunke, Dong, Minjing, Xu, Chang, Du, Bo, Zhao, Yukun   +4 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Combining exploration and imitation in contact-rich task learning on an articulated soft robot arm. [PDF]

Front Robot AI
Elstner L, Kyrkjebø E, Stoelen MF.
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Assessing Student Satisfaction With Teaching-Learning Methods in Postgraduate Anaesthesiology: Nationwide Survey Based Analysis. [PDF]

Cureus
Jain A, Singh MK, Mittal AA, K R, Jain G, Sinha R, Achari S, Verma B.   +7 more
europepmc   +1 more source

Demonstrations Against Demonstrations

, 2017
This article shows how, in the midst of the patriotic fervour following the Crimea annexation, the Russian regime used mass demonstrations to pacify the population. Rather than mobilizing people to actively participate in pro-regime, anti-opposition rallies, Kremlin spin doctors used social media to spread moods of sadness and fear in order to ...
openaire   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

It's not who you know: sociometric position did not shape children's innovation or imitation propensities. [PDF]

Front Psychol
Rawlings B, Flynn E, Kendal R.
europepmc   +1 more source