Results 171 to 180 of about 605,142 (290)

Real-world application of an eye-tracking device for autism screening and diagnosis: a short report from public demonstrations in Qatar, Dubai and the U.S. [PDF]

BMC Psychiatry
Al Shaban F, Frazier TW, Ghazal I, Al-Faraj F, Aqel S, Thompson IR.   +5 more
europepmc   +1 more source

Demonstration on Demonstrator Component

A technical report whereby the benefits of the PASSPORT software will be demonstrated by building a part using “best practice” versus the method from the ...
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Solving robotics tasks with prior demonstration via exploration-efficient deep reinforcement learning. [PDF]

Front Robot AI
Shen C, Sloth C.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Fast reprogramming and adaptive reproduction of contact-rich assembly. [PDF]

Front Robot AI
Rakovitis D, Origanti VK, Bargsten V, Danzglock A, Mronga D, Kirchner F.   +5 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Comment on: Antagonistic in vitro interaction between olorofim and voriconazole against Aspergillus fumigatus. [PDF]

J Antimicrob Chemother
Pinder C, Birch M, Oliver JD, Law D, Zinzi D, Rex JH.   +5 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Revealing emergent human-like conceptual representations from language prediction. [PDF]

Proc Natl Acad Sci U S A
Xu N, Zhang Q, Du C, Luo Q, Qiu X, Huang X, Zhang M.   +6 more
europepmc   +1 more source