Results 131 to 140 of about 114,451 (337)
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
The Chinese copula SHI and Its Origin: A Congnitive-based Approach [PDF]
, 2006 This paper discusses the proposals of Li and Thompson (1977), Yen (1986), and Feng (1993) in relation to the development of the Chinese copula and argues that Li and Thompson’s suggestion of a topic mechanism, Yen’s analogical change, and Feng’s ...
Jung-hsing Chang
core
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Aristotle’s theory of language in the light of Phys. I.1 [PDF]
, 2018 The main aim of my paper is to analyse Aristotle’s theory of language in the context of his Physics I.1 and via an analysis and an interpretation of this part of his Physics I try to show that (i) the study of human language (logos) significantly falls ...
Labuda, Pavol
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Cogent EducationThis study aims to investigate the effects of deductive and inductive instructions on the acquisition of English demonstrative determiners by 78 Arabic-speaking 4th graders in an attempt to determine which of the two instructions is more effective.
Abdel Rahman Mitib Altakhaineh +3 more
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Demonstrative of cancer in lungs utilizing CT scan in DL [PDF]
, 2020 Ramani Nakka
openalex +1 more source