Results 201 to 210 of about 90,516 (299)

Oligodendrocyte‐Targeted SGK1.1 Inhibition Alleviates White Matter Injury and Cognitive Impairment in Alzheimer's Disease via Modulation of HDAC2 Phosphorylation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
We found an early Sgk1.1 mRNA upregulation within oligodendrocyte‐lineage cells of 5 × FAD mice, implicating SGK1.1 signaling as an early driver of myelin pathology. Mechanistically, SGK1.1 promotes HDAC2 phosphorylation at S422/S424, thereby impairing oligodendrocyte maturation.
Shiji Deng, Shenghan Gao, Chao Zhou, Zhen Lan, Huiya Li, Jiang Chen, Yuhao Xu, Jiashuo Li, Pinyi Liu, Siyuan Zhang, Xinyu Bao, Tingting Wang, Yun Xu, Xiaolei Zhu   +13 more
wiley   +1 more source

Beyond dissemination criteria: lesion-based longitudinal MRI of atypical demyelinating lesions at the boundary of multiple sclerosis. [PDF]

J Neurol
Aratake Y, Yoshinaga K, Ashida S, Fujii C, Hamatani M, Kimura K, Ochi H, Takahashi R, Kondo T.   +8 more
europepmc   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

Demyelination [PDF]

, 2011
  +4 more sources

Oligodendroglia as Active Immunomodulators in Demyelinating Diseases. [PDF]

Neurosci Bull
Park J, Cheon SY, Barman B, Guo F.
europepmc   +1 more source

Clinical spectrum and prognostic features of patients seropositive for anti-GD1a antibody. [PDF]

Front Immunol
Chu X, Liu X, Zeng Z, Li J, Liu X, Guo S, Wu R.   +6 more
europepmc   +1 more source

Administration of Schwann Cell‐Like Cells Differentiated From Tonsil‐Derived Mesenchymal Stem Cells Promotes Peripheral Nerve Regeneration by Inducing Macrophage Polarization in a Chronic Constriction Injury Model

Muscle &Nerve, Volume 74, Issue 3, Page 728-739, September 2026.
TMSC‐SCs were mixed with fibrin adhesive and administered into the sciatic nerve of CCI rats, and nerve conduction studies and histopathological observations confirmed the regeneration of the peripheral nerve and gastrocnemius muscle. In addition, the expression of M1 and M2 macrophage markers was observed after the administration of TMSC‐SCs. ABSTRACT
Yu Hwa Nam, Ji‐Sup Kim, Yoonji Yum, Juhee Yoon, Youbeen Cho, Jaeseung Lim, Saeyoung Park, Sung‐Chul Jung   +7 more
wiley   +1 more source

Synchronous Late-Onset of Limbic Encephalitis and Tumefactive Demyelinating Lesion After the End of Immunotherapy. [PDF]

Clin Nucl Med
Baehr M, Schellinger PD, Borggrefe J, Surov A.   +3 more
europepmc   +1 more source

POEMS syndrome presenting as presumed chronic glomerulonephritis with a 1-year delay in diagnosis: a case report. [PDF]

Front Med (Lausanne)
Liu L, Li M, Li F.
europepmc   +1 more source

Possible Contribution of Multiple Sclerosis Pathology to Treatment‐Resistant Schizophrenia: A Case Study

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
A case of multiple sclerosis detected by brain MRI during evaluation for modified electroconvulsive therapy in the long‐term course of schizophrenia. This case discusses the clinical overlap between multiple sclerosis pathology and treatment‐resistant schizophrenia. ABSTRACT Multiple sclerosis (MS) can present with neurological and psychiatric symptoms
Sho Miura, Atsuko Nagaoka, Mizuki Hino, Risa Shishido, Masataka Hatano, Yuto Hosogai, Kazusa Miyahara, Yuta Oba, Kimihiko Kaneko, Yasuto Kunii, Hiroaki Tomita   +10 more
wiley   +1 more source