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Anaesthesia and demyelinating disease [PDF]

Anaesthesia, 1980
SummaryThe demyelinating diseases are classified and the current concepts of the aetiology and pathophysiology of the most common of these diseases, multiple sclerosis, are described. The effects of the impaired function, local responses and known complications of the disease on the choice of anaesthetic, drugs and techniques are discussed.
T. E. J. Healy, Ronald M. Jones
openaire   +3 more sources

18F-Fluorodeoxy Glucose and 11C-Methionine Accumulation in Demyelinating Lesions

World Journal of Nuclear Medicine, 2022
Background Few studies have evaluated the accumulation of 18F-fluorodeoxyglucose (FDG), 11C-methionine (MET), and other positron emission tomography (PET) tracers in patients with demyelinating disease.
Noriaki Tomura, Toshiyuki Saginoya, Chikako Kaneko   +2 more
doaj   +1 more source

Antibodies to MOG in adults with inflammatory demyelinating disease of the CNS

Neurology: Neuroimmunology & Neuroinflammation, 2015
Objective: To evaluate the clinical relevance of myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in a cohort of adults with inflammatory demyelinating disease (IDD) of the CNS.
Sung-Min Kim, M. Woodhall, Ji-Sun Kim, Seong-Joon Kim, K. Park, A. Vincent, Kwang‐Woo Lee, P. Waters   +7 more
semanticscholar   +1 more source

AhR-deficiency as a cause of demyelinating disease and inflammation

Scientific Reports, 2017
The Aryl hydrocarbon Receptor(AhR) is among the most important receptors which bind pollutants; however it also regulates signaling pathways independently of such exposure.
Ludmila Juricek, Julie Carcaud, Alice Pelhaître, Thorfinn T. Riday, A. Chevallier, Justine Lanzini, N. Auzeil, O. Laprévote, F. Dumont, S. Jacques, F. Letourneur, C. Massaad, C. Agulhon, R. Barouki, M. Beraneck, X. Coumoul   +15 more
semanticscholar   +1 more source

Quantitative determination of regional lesion volume and distribution in children and adults with relapsing-remitting multiple sclerosis.

PLoS ONE, 2014
IntroductionOnset of MS occurs during childhood in about 5% of cases. It is unclear whether very young age at MS onset, when the nervous system is still myelinating, affects MS lesion accrual or regional distribution.ObjectiveTo compare the frequency ...
Rezwan Ghassemi, Sridar Narayanan, Brenda Banwell, John G Sled, Manohar Shroff, Douglas L Arnold, Canadian Pediatric Demyelinating Disease Network   +6 more
doaj   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate whether the rs10191329 risk allele in the DYSF–ZNF638 locus, which is implicated in central nervous system resilience rather than immune‐mediated pathology, is associated with retinal layer thinning, a biomarker of neuroaxonal damage in relapsing multiple sclerosis (RMS). Methods From a prospective observational study,
Gabriel Bsteh, Ruchi Tanavade, Nik Krajnc, Fabian Föttinger, Theresa König, Martin Krenn, Lukas Haider, Barbara Kornek, Fritz Leutmezer, Kerstin U. Ludwig, Stefan Macher, Tobias Monschein, Markus Ponleitner, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Tobias Zrzavy, Gudrun Zulehner, Franziska Di Pauli, Axel Schmidt, Harald Hegen, Berthold Pemp, Thomas Berger   +22 more
wiley   +1 more source

FcγRIIb Expression Is Decreased on Naive and Marginal Zone-Like B Cells From Females With Multiple Sclerosis

Frontiers in Immunology, 2021
B cells are critical to the development of multiple sclerosis (MS), but the mechanisms by which they contribute to the disease are poorly defined. We hypothesised that the expression of CD32b (FcγRIIb), a receptor for the Fc region of IgG with inhibitory
Stephanie Trend, Stephanie Trend, Jonatan Leffler, Ingrid Teige, Björn Frendéus, Allan G. Kermode, Allan G. Kermode, Martyn A. French, Prue H. Hart   +8 more
doaj   +1 more source

Analysis of Soluble Interleukin‐2 Receptor as a Prognostic Biomarker in NMOSD and MOGAD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Soluble interleukin‐2 receptor (sIL‐2R) is a biomarker for T cell activity. T cells are involved in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) pathogenesis. However, sIL‐2R has so far not been evaluated in these conditions.
Philipp Klyscz, Carolin Otto, Klemens Ruprecht, Susanna Asseyer, Hannes Ole Tiedt, Christian Meisel, Judith Bellmann‐Strobl, Friedemann Paul, Patrick Schindler   +8 more
wiley   +1 more source

Glutamate Receptors in Neuroinflammatory Demyelinating Disease

Mediators of Inflammation, 2006
Multiple sclerosis (MS) is a chronic demyelinating disease of the human central nervous system (CNS). The condition predominantly affects young adults and is characterised by immunological and inflammatory changes in the periphery and CNS that contribute
Christopher Bolton, Carolyn Paul
doaj   +2 more sources