Results 121 to 130 of about 76,100 (290)

Improved UNet‐based magnetic resonance imaging segmentation of demyelinating diseases with small lesion regions

Cognitive Computation and Systems, EarlyView.
Abstract Accurate magnetic resonance imaging (MRI) segmentation plays a critical role in the diagnosis and treatment of demyelinating diseases. But the existing automatic segmentation methods are not suitable for the segmentation of demyelinating lesions with small lesion size, highly diffuse edges and complex boundary shapes.
Minhui Liu, Tianlei Wang, Dekang Liu, Feng Gao, Jiuwen Cao   +4 more
wiley   +1 more source

Genetic Pigmentary Disorders: From Molecular Mechanisms to Clinical Manifestations

The Journal of Dermatology, EarlyView.
ABSTRACT Genetic pigmentary disorders represent a diverse group of genetic conditions characterized by alterations in melanin production and transport and melanocyte development, resulting from single‐gene pathological variants. These disorders encompass both hypopigmentary and hyperpigmentary phenotypes, affecting not only skin pigmentation but also ...
Ken Okamura, Tamio Suzuki
wiley   +1 more source

The Role of Microorganisms in the Etiopathogenesis of Demyelinating Diseases. [PDF]

Life (Basel), 2023
Frau J, Coghe G, Lorefice L, Fenu G, Cocco E.   +4 more
europepmc   +1 more source

Representing disease courses: An application of the Neurological Disease Ontology to Multiple Sclerosis Typology [PDF]

, 2013
The Neurological Disease Ontology (ND) is being developed to provide a comprehensive framework for the representation of neurological diseases (Diehl et al., 2013).
Cox, Alexander P., Diehl, Alexander, Jensen, Mark, Smith, Barry   +3 more
core  

Drug‐Induced Periocular and Ocular Surface Disorders: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Various systemic and topical medications can induce ocular and periocular cutaneous adverse effects (AEs), ranging from mild to severe. These AEs may lead to ocular surface (OS) damage and, in some cases, life‐threatening complications. Drug‐induced ocular adverse reactions are generally classified into two primary categories: toxic reactions ...
Andrea Leonardi, Banu Bozkurt, Diana Silva, Charlotte G. Mortz, Christophe Baudouin, Marina Atanaskovic‐Markovic, Vibha Sharma, Serge Doan, Shweta Agarwal, Daniel Pérez‐Formigo, Maria Joao Vasconcelos, Francoise‐Brignole Baudouin, Gonzalo Chorzepa, Jean‐Luc Fauquert, Virginia Calder, Pascal Demoly, Luis Delgado   +16 more
wiley   +1 more source

The impact of gut microbiome on neuro-autoimmune demyelinating diseases

Academia Biology
Demyelinating diseases, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and chronic inflammatory demyelinating polyneuropathy (CIDP), are characterized by dysregulated immune responses to self-antigens ...
Pouria Abolfazli, Cristina Nkene Apue Nchama, Brandon Lucke-Wold   +2 more
doaj   +1 more source

Viruses and Demyelinating Diseases [PDF]

, 1985
D. Graham
openalex   +1 more source

Dysregulation of the endosomal sorting complex III is linked to neurodegeneration in progressive multiple sclerosis

Brain Pathology, EarlyView.
This study shows that components of the ESCRT‐III membrane repair machinery, VPS4B and CHMP2A, are dysregulated in progressive MS and are associated with higher neurodegeneration and inflammation. This might lead to improper function of the complex to inhibit the final stages of necroptosis activation and thus impede neuronal cell death.
Carmen Picon, Robertas Aleksynas, Marcelina Wojewska, Francesco de Virgiliis, Doron Merkler, Richard Reynolds   +5 more
wiley   +1 more source

Neurofilament light chain as a marker of peripheral nerve damage in vasculitic neuropathy? A cross‐compartmental correlation analysis in patients undergoing nerve biopsy

Brain Pathology, EarlyView.
To assess neurofilament light chain (NfL) as a biomarker of peripheral nerve damage, we correlated serumNfL concentrations with histopathological parameters from matched sural nerve biopsies. SerumNfL levels correlated with markers of acute axonal degeneration, but not with parameters reflecting chronic axonal loss.
Simon Streit, Jenny Meinhardt, Niclas Gimber, John Kestenbach, Christin Siewert, Jan Schmoranzer, Christian Meisel, Klemens Ruprecht, Frank L. Heppner, Péter Körtvélyessy, Werner Stenzel   +10 more
wiley   +1 more source

Optic neuritis: a comprehensive review of current therapies and emerging treatment strategies

Frontiers in Neurology
BackgroundOptic neuritis (ON) is an inflammatory condition of the optic nerve that can lead to significant visual impairment. It is often associated with multiple sclerosis (MS) but can also occur in other demyelinating diseases, such as neuromyelitis ...
Pareena Chaitanuwong, Pareena Chaitanuwong, Heather E. Moss, Heather E. Moss   +3 more
doaj   +1 more source