Results 141 to 150 of about 44,319 (309)

Unexpected Remyelination in the Absence of Matrix Metalloproteinase 7

Glia, EarlyView.
MMP7 is not essential for demyelination and remyelination in the cuprizone model. In MMP7−/− mice fibronectin aggregates do not accumulate in the remyelination phase. MMP7−/− mice have lower levels of fibronectin and hyaluronan after chronic demyelination.
Rianne P. Gorter, Andrea J. Arreguin, Wendy Oost, Jenny C. de Jonge, Harm H. Kampinga, Sandra Amor, Holly Colognato, Wia Baron   +7 more
wiley   +1 more source

Correlation between patient‐reported manual ability and three objective measures of upper limb function in people with multiple sclerosis

European Journal of Neurology, Volume 30, Issue 1, Page 172-178, January 2023., 2023
Abstract Background and purpose Upper limb (UL) function is often affected in people with multiple sclerosis (PwMS) and is typically assessed through objective measures, including the Nine Hole Peg Test (9‐HPT), Box and Block Test (BBT), and Hand Grip Strength (HGS). It is important to include the subjective perspective of PwMS in the assessment.
Claudio Solaro, Rachele Di Giovanni, Erica Grange, Giampaolo Brichetto, Margit Mueller, Andrea Tacchino, Rita Bertoni, Francesco Patti, Angelo Pappalardo, Luca Prosperini, Letizia Castelli, Rosalba Rosato, Davide Cattaneo, Davide Marengo   +13 more
wiley   +1 more source

Guillain-Barré syndrome: a century of progress [PDF]

, 2016
In 1916, Guillain, Barré and Strohl reported on two cases of acute flaccid paralysis with high cerebrospinal fluid protein levels and normal cell counts — novel findings that identified the disease we now know as Guillain–Barré syndrome (GBS).
A Campbell, A Chiba, A Chiba, A Pestronk, A Uncini, AA Ilyas, AD Langmuir, AJ Sumner, AK Asbury, AK Asbury, AK Asbury, AM Fitzpatrick, B Parra, B van den Berg, BH Waksman, C Brechenmacher, C Fokke, C Hafer-Macko, C Linington, CE Hafer-Macko, CL Schengrund, CP O'Leary, E Díez-Tejedor, FG van der Meché, FH Geisler, G Guillain, GM McKhann, GM O'Hanlon, H Wis´niewski, HJ Willison, Hugh J. Willison, J Kaldor, J Matias-Guiu, JA Goodfellow, JC Dodge, JG McLeod, JH Rees, JJ Plomp, JM Pearce, John A. Goodfellow, JW Albers, JW Griffin, JW Prineas, K Kaida, K Susuki, KE Astrom, KM Rhodes, KN Greenshields, LB Schonberger, LD Osler, LM Araujo, LT Kurland, M Fisher, M Kadlubowski, M Vermeulen, MK White, N Shahrizaila, N Yuki, N Yuki, N Yuki, N Yuki, NA Gregson, O Landry, PA van Doorn, PO Osterman, R McGonigal, R McGonigal, R van Koningsveld, RA Hughes, RA Hughes, RJ Greenwood, RP Kleyweg, S Draganescu, S Kusunoki, S Lafontaine, S Rinaldi, S Rinaldi, S Rinaldi, SK Halstead, SK Halstead, SK Halstead, T Lasky, T Saida, TE Feasby, TE Feasby, TW Ho, TW Ho, VM Cao-Lormeau, W Wiederholt, W Yan, WE Haymaker, Y Nagai   +91 more
core   +1 more source

Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged Mice

Glia, EarlyView.
Ablation of autophagy in oligodendrocytes reveals increased PLP expression, myelin abnormalities, axon degeneration, and increased microglia activation in aged mice. The aged mice exhibit marked deficits in learning and memory tasks. ABSTRACT The aging central nervous system (CNS) is often marked by myelin degeneration, yet the underlying mechanisms ...
Niki Ktena, Dimitrios Spyridakos, Alexandros Georgilis, Ilias Kalafatakis, Efstathia Thomoglou, Angeliki Kolaxi, Vassiliki Nikoletopoulou, Maria Savvaki, Domna Karagogeos   +8 more
wiley   +1 more source

Clinical characteristics, treatments, outcome, and prognostic factors of severe autoimmune encephalitis in the intensive care unit: Standard treatment and the value of additional plasma cell–depleting escalation therapies for treatment‐refractory patients

European Journal of Neurology, Volume 30, Issue 2, Page 474-489, February 2023., 2023
Our retrospective study analyzed 40 patients with intensive care unit (ICU)‐dependent autoimmune encephalitis (AE) for clinical characteristics, diagnostics, prognostic factors, and clinical outcomes regarding standard treatment in responsive patients versus additional escalation therapies for treatment‐refractory cases.
Lisa Schwarz, Nilufar Akbari, Harald Prüss, Andreas Meisel, Franziska Scheibe   +4 more
wiley   +1 more source

Tumefactive Brain Demyelination Accompanying MADSAM Neuropathy

Türk Nöroloji Dergisi, 2015
Multifocal acquired demyelinating sensory and motor (MADSAM) neuropathy is characterized by asymmetric multifocal motor and sensory loss and conduction blocks in peripheral nerves.
Şefik Evren Erdener, Çağrı Mesut Temuçin, Figen Söylemezoğlu, Rahşan Göçmen, Aslı Tuncer Kurne   +4 more
doaj   +1 more source

Diagnosis and treatment of progressive multiple sclerosis: A position paper

European Journal of Neurology, Volume 30, Issue 1, Page 9-21, January 2023., 2023
Abstract Background and Purpose Multiple sclerosis (MS) is an unpredictable disease characterised by a highly variable disease onset and clinical course. Three main clinical phenotypes have been described. However, distinguishing between the two progressive forms of MS can be challenging for clinicians.
Carlo Pozzilli, Maura Pugliatti, Patrick Vermersch, Nikolaos Grigoriadis, Mona Alkhawajah, Laura Airas, Celia Oreja‐Guevara   +6 more
wiley   +1 more source

ACUTE DEMYELINATING DISEASE COMPLICATING HERPES ZOSTER [PDF]

, 1959
Douglas McAlpine, Yoshigoro Kuroiwa, Y Toyokura, Sumio Araki   +3 more
openalex   +1 more source

Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]

, 2016
Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai, Liu, Yan-Qun, Xie, Chong, Zhang, Guang-Xian   +3 more
core   +2 more sources

Investigating the role of SARM1 in central nervous system

Ibrain, EarlyView.
Sterile‐α and Toll/interleukin 1 receptor (TIR) motif‐containing protein 1 (SARM1) is a pivotal molecule that has garnered extensive attention in neuroscience. As an intracellular molecule, SARM1 possesses various crucial biological functions in the nervous system.
Junjie Wang, Yuhang Shi, Jinglei Tian, Liming Tang, Fang Cao   +4 more
wiley   +1 more source