Results 161 to 170 of about 2,126,593 (244)

Tacrolimus‐Induced Atypical Posterior Reversible Encephalopathy Syndrome (PRES) in a Kidney Transplant Recipient: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT We report a 36‐year‐old woman who presented with acute visual hallucinations, delusions, and dizziness 2 months after uncomplicated kidney transplantation. Brain magnetic resonance imaging (MRI) revealed T2/FLAIR hyperintensities in the dorsal pons and bilateral temporal cortices, atypical yet consistent with PRES.
Roya Sadeghnia, Sayed Mortaza Fayez, Sara Samadi   +2 more
wiley   +1 more source

Unexpected Conduction Blocks in SORD‐Related Distal Motor Neuropathy: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Distal weakness requires an extensive differential diagnosis. In this case, conduction blocks indicated multifocal motor neuropathy, but immunotherapy proved ineffective. Ultimately, genetic testing revealed a sorbitol dehydrogenase mutation, highlighting the importance of combining electrophysiological findings with molecular studies in cases
Amiela Angeli Bucur, Gabriele Rodolico, Alessandra Tessa, Filippo Maria Santorelli, Martina Sperti, Deborah Leccese, Mario Maturo, Sabrina Matà   +7 more
wiley   +1 more source

Spinal Cord Sarcoidosis Treated With Infliximab

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Isolated spinal cord lesion could be misinterpreted as a demyelinating disease. The diagnosis of sarcoidosis should be in the differential when other indices for a demyelinating disorder are absent. An inadequate response to intravenous steroid therapy should not rule out spinal sarcoidosis as this report confirms the response to intravenous ...
Hussein Moussa, Roula Hourani Rizk, Nina S. Shabb, Nabil El Ayoubi, Raja Sawaya   +4 more
wiley   +1 more source

Anti‐TNF‐Alpha Associated Central Nervous System Demyelination. Drug‐Induced Demyelination or Multiple Sclerosis Trigger? A Case Series

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Adalimumab is a monoclonal antibody that targets TNF‐α and is effective in treating several autoimmune disorders, including non‐infectious uveitis; however, it has been associated with demyelinating lesions. This study presents two cases of CNS demyelination in patients who consumed adalimumab. First, an 18‐year‐old man presented with subacute
Marzie Abutorabi‐zarchi, Amin Ziyaei, Davoud Ghane   +2 more
wiley   +1 more source

Prolonged Headache in a 13‐Year‐Old Girl With Acute Lymphoblastic Leukemia: A Case of Possible Neuroinflammatory Complication Responsive to Intravenous Immunoglobulin

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Neurological complications in pediatric acute lymphoblastic leukemia (ALL) may result from disease, CNS involvement, or treatment. We report a 13‐year‐old girl with persistent headache and blurred vision suggestive of raised intracranial pressure.
Amereh Hadizadeh, Hossein Esfahani, Firozeh Hosseini, Afshin Fayyazi, Nasibeh Ghalandari   +4 more
wiley   +1 more source

Parvalbumin interneurons in Alzheimer's disease: Physiological insights and pathophysiological mechanisms

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Physiological and Pathological Alterations in PV+ Neurons: Under physiological conditions, PV+ interneurons exhibit fast‐spiking properties and generate gamma oscillations at the cost of high energy consumption. In AD, PV+ neurons display abnormalities in ion channels, dendrites, neurotransmission, energy metabolism, and neural oscillations, ultimately
Mengyan Wu, Xingdong Zeng, Yongle Cai, Haonan Chen, Qianying Li, Hao Yang   +5 more
wiley   +1 more source

Crosstalk Between Cortical Plasticity and Peripheral Nervous Injury: Insights, Mechanisms, and Future Directions

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Peripheral nerve injury induces dynamic cortical plasticity, driven by molecular mechanisms such as BDNF and neurotransmitter systems. This review synthesizes subtype‐specific plasticity patterns: compressive injuries trigger rapid reorganization, while metabolic neuropathies lead to maladaptive changes.
Cong Cheng, Dong Gao, Yaojie Shen, Xi Wang, Junxi Dai, Yaoxian Xiang, Zongyuan Jiang, Zongqi You, Junjian Jiang   +8 more
wiley   +1 more source

Prefrontal Neurovascular Coupling Abnormalities Associated With Cognitive Performance in Multiple Sclerosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Multimodal MRI showed reduced global CBF‐ALFF coupling and increased medial prefrontal CBF/ALFF ratios in multiple sclerosis. The mPFC abnormality was associated with lower cognitive performance and greater disability. ABSTRACT Background Cognitive impairment is a prevalent and debilitating feature in multiple sclerosis (MS), yet its pathophysiology ...
Ruisi Gong, Hao Zhang, Jinlin Jiao, Lei Liu, Xiaohan Xu, Huiwen Song, Yuexin Zhou, Yuanjie Duan, Hefei Fu, Jibin Cao, Lingling Cui   +10 more
wiley   +1 more source

Oligodendrocyte‐Targeted SGK1.1 Inhibition Alleviates White Matter Injury and Cognitive Impairment in Alzheimer's Disease via Modulation of HDAC2 Phosphorylation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
We found an early Sgk1.1 mRNA upregulation within oligodendrocyte‐lineage cells of 5 × FAD mice, implicating SGK1.1 signaling as an early driver of myelin pathology. Mechanistically, SGK1.1 promotes HDAC2 phosphorylation at S422/S424, thereby impairing oligodendrocyte maturation.
Shiji Deng, Shenghan Gao, Chao Zhou, Zhen Lan, Huiya Li, Jiang Chen, Yuhao Xu, Jiashuo Li, Pinyi Liu, Siyuan Zhang, Xinyu Bao, Tingting Wang, Yun Xu, Xiaolei Zhu   +13 more
wiley   +1 more source

Emodin Suppresses the RAGE/ROCK1 Pathway to Modulate the Oligodendrocyte Lineage and Ameliorate Demyelination in Vascular Dementia Rats

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Emodin improves white matter remyelination and alleviates cognitive deficits through suppression of the RAGE/ROCK1 signaling pathway in VD rats. Mechanistically, it modulates the OL lineage by reducing the elevated proliferative response of OPCs while promoting their maturation and remyelination.
Xueqing Wang, Xiumei Dong, Cunbao He, Junjie Zhang, Wenming Ban, Guoqi Zhu, Jingji Wang, Yilan Zhen   +7 more
wiley   +1 more source