Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice [PDF]
, 1990 Amy K. Patick +3 more
openalex +1 more source
DLK/JNK3 Upregulation Aggravates Hair Cell Senescence in Mice Cochleae via Excessive Autophagy
Aging Cell, EarlyView.In normal physiological processes, autophagy acts as a protective factor against aging stress. With the stress increase, the DLK/JNK3 pathway is activated and autophagy is continuously upregulated. In our study, excessive autophagy leads to hair cell senescence, which reveals that excessive autophagy can play a harmful role in senescence under certain ...
Rui Ding +8 more
wiley +1 more source
In Vivo and in Vitro Models of Demyelinating Disease. Possible Relationship between Induction of Regulatory Subunit from cAMP Dependent Protein Kinases and Inhibition of JHMV Replication in Cultured Oligodendrocytes [PDF]
, 1990 Greame A. R. Wilson +2 more
openalex +1 more source
Rare but relevant: Nitrous oxide and peripheral neurotoxicity, what do we know?
Addiction, Volume 120, Issue 5, Page 1046-1050, May 2025.Abstract Nitrous oxide (N2O), used medically as an anaesthetic, has gained popularity as a recreational drug, with rising prevalence particularly among young adults. While its reinforcing and addictive potential remains debated, N2O is proven to be neurotoxic, especially with prolonged, heavy use, which is often unexpected for users.
Tibor M. Brunt +2 more
wiley +1 more source
A Guide to Screening for Autoimmune Diseases in Patients With Vulvar Lichen Sclerosus
Australasian Journal of Dermatology, Volume 66, Issue 3, Page 135-141, May 2025.ABSTRACT Background The aetiology of vulvar lichen sclerosus (VLS) remains unknown. However, there is evidence that in addition to a genetic predisposition, autoimmunity contributes to the pathogenesis. Objectives The objective of this study was to determine the prevalence of autoimmune disease and positive autoantibody serology in patients with VLS ...
Annabel Guttentag +5 more
wiley +1 more source
Ontologies for the study of neurological disease [PDF]
, 2012 We have begun work on two separate but related ontologies for the study of neurological diseases. The first, the Neurological Disease Ontology (ND), is intended to provide a set of controlled, logically connected classes to describe the range of ...
Cox, Alexander P. +7 more
core
Brain Pathology, Volume 35, Issue 3, May 2025.In progressive MS, mixed active plaques and perivascular inflammation in the sub/juxtacortical white matter correlate with similar (albeit fainter) pathologies in the cortical parenchyma Abstract It remains elusive whether lesions and inflammation in the sub/juxtacortical white matter reflect cortical and/or meningeal pathologies.
Betül Okutan +10 more
wiley +1 more source
Brain Pathology, EarlyView.Graphical representation of the widespread white matter (blue color mask) and grey matter (cortical and deep grey matter; red color mask) demyelination in MS cases characterized by substantial inflammation of the CP (A). The presence of lesions was mainly associated with periventricular white matter and hippocampus areas (A).
R. Magliozzi +19 more
wiley +1 more source
Editorial: Epidemiology of Atypical Demyelinating Diseases
Frontiers in Neurology, 2021 Dalia Rotstein +4 more
doaj +1 more source