Results 111 to 120 of about 54,440 (362)

Cationic Dendrimer G2-S16 Inhibits Herpes Simplex Type 2 Infection and Protects Mice Vaginal Microbiome

Pharmaceutics, 2020
The G2-S16 polyanionic carbosilane dendrimer is a promising microbicide that inhibits HSV-2 infection in vitro and in vivo in mice models. This G2-S16 dendrimer inhibits HSV-2 infection even in the presence of semen.
Carlos Guerrero-Beltrán, Inmaculada Garcia-Heredia, Rafael Ceña-Diez, Ignacio Rodriguez-Izquierdo, María Jesús Serramía, Francisco Martinez-Hernandez, Mónica Lluesma-Gomez, Manuel Martinez-Garcia, María Ángeles Muñoz-Fernández   +8 more
doaj   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Dendrimers for theranostic applications

Biomolecular Concepts, 2015
AbstractRecently, there have been tremendous advances in the development of various nanotechnology-based platforms for diagnosis and therapy. These nanoplatforms, which include liposomes, micelles, polymers, and dendrimers, comprise highly integrated nanoparticles that provide multiple functions, such as targeting, imaging, and therapy.
Chie Kojima, Ugir Hossain Sk
openaire   +4 more sources

Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease

Aggregate, EarlyView.
This review introduces the light‐regulated Aβ aggregation, highlighting four applications: photodynamic therapy (PDT), photothermal therapy (PTT), photopharmacology, and photobiomodulation (PBM) systems. It also summarizes the current issues and proposes the prospects of photo‐induced modulation of Aβ aggregation and clearance as a therapeutic strategy
Yunhua Zhang, Chengyuan Qian, Yuncong Chen, Weijiang He, Zijian Guo   +4 more
wiley   +1 more source

Dynamic responsiveness of self‐assembling peptide‐based nano‐drug systems

Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023
This review discusses dynamically responsive self‐assembling peptide‐based nano‐drug systems, including the stimulation response, strategy of biomimicry, subcellular internalization, and the applications of peptide nano‐drug materials, and concludes with a brief outlook of their challenges and opportunities in clinical translation.
Yuhan Wang, Jie Zhan, Jinyan Huang, Xing Wang, Zehong Chen, Zhimou Yang, Jie Li   +6 more
wiley   +1 more source

Adaptive amphiphilic dendrimer-based nanoassemblies as robust and versatile siRNA delivery systems.

Angewandte Chemie, 2014
siRNA delivery remains a major challenge in RNAi-based therapy. Here, we report for the first time that an amphiphilic dendrimer is able to self-assemble into adaptive supramolecular assemblies upon interaction with siRNA, and effectively delivers siRNAs
Xiaoxuan Liu, Jiehua Zhou, Tianzhu Yu, Chao Chen, Qiang Cheng, K. Sengupta, Yuanyu Huang, Haitang Li, Cheng Liu, Yang Wang, P. Posocco, Menghua Wang, Qi Cui, S. Giorgio, M. Fermeglia, Fanqi Qu, S. Pricl, Yanhong Shi, Zicai Liang, P. Rocchi, J. Rossi, Ling Peng   +21 more
semanticscholar   +1 more source

Hydrogel‐Based Smart Materials for Wound Healing and Sensing

Aggregate, EarlyView.
The graphical abstract illustrates the role of hydrogel‐based flexible materials in advancing biomedical applications, including wound healing, point‐of‐care diagnostics, smart patches, and wearable devices. Hydrogels are particularly promising in modern wound care due to their high‐water content, flexibility, and biocompatibility.
Thi Kim Ngan Duong, Thi Thuy Truong, Thi Nhat Linh Phan, Thi Xuan Nguyen, Vu Hoang Minh Doan, Truong Tien Vo, Jaeyeop Choi, Umapada Pal, Prodyut Dhar, Byeongil Lee, Junghwan Oh, Sudip Mondal   +11 more
wiley   +1 more source

Progress and challenges of mRNA vaccines

Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023
As the third‐generation nucleic acid vaccine, the Messenger RNA (mRNA) vaccine stimulates a specific immune response by introducing mRNA expressing the target antigen into the body through a specific delivery system and expressing the corresponding protein.
Liangru Lin, Yusheng Pei, Zhou Li, Dan Luo   +3 more
wiley   +1 more source

Multiscale Modeling of Dendrimers and Their Interactions with Bilayers and Polyelectrolytes

Molecules, 2009
Recent advances in molecular dynamics simulation methodologies and computational power have allowed accurate predictions of dendrimer size, shape, and interactions with bilayers and polyelectrolytes with modest computational effort.
Ronald G. Larson, Hwankyu Lee
doaj   +1 more source

Dendrimer advances for the central nervous system delivery of therapeutics.

ACS Chemical Neuroscience, 2014
The effectiveness of noninvasive treatment for central nervous system (CNS) diseases is generally limited by the poor access of therapeutic agents into the CNS.
Leyuan Xu, Hao Zhang, Yue Wu
semanticscholar   +1 more source