Results 51 to 60 of about 3,456,325 (296)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Free subgroups of dendrite homeomorphism group [PDF]

, 2012
An action of a group G on a topological space X is called minimal if for every point x∈X, the orbit Gx of x is dense in X. A connected and locally connected compact metric space which contains no simple closed curve is called a dendrite.
Shi, Enhui
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Bimetal-Initiated Concerted Zn Regulation Enabling Highly Stable Aqueous Zn-Ion Batteries

Batteries
Aqueous zinc ion batteries are highly sought after for the next generation of sustainable energy storage systems. However, their development is significantly impeded by the presence of undesired zinc dendrites, which greatly reduce their cycle life.
Hong Yin, Yuliang Liu, Yifeng Zhu, Fengxiang Ye, Guangliang Xu, Mengfang Lin, Wenbin Kang   +6 more
doaj   +1 more source

Designing Zinc Deposition Substrate with Fully Preferred Orientation to Elude the Interfacial Inhomogeneous Dendrite Growth

Research, 2022
The development of zinc-ion batteries with high energy density remains a great challenge due to the uncontrollable dendrite growth on their zinc metal anodes.
Chunlin Xie, Zefang Yang, Qi Zhang, Huimin Ji, Yihu Li, Tingqing Wu, Wenbin Li, Pengfei Wu, Haiyan Wang   +8 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Laser-engraved graphene architecture as an ultra-light freestanding lithium-free anode for lithium batteries

Nano Research
Breakthroughs in high-capacity anodes represent a critical frontier in the development of next-generation high-specific-energy storage systems. However, the current high-capacity anodes of lithium batteries are confronted with numerous challenges ...
Jinze He, Lun Li, Rui Tan, Huazhang Zhang, Jie Wen, Mingxuan Wu, Chao Yin, Lai Tong, Lvping Fu, Biao Gao, Jinlong Yang, Daping He   +11 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Boosting the Performance of Lithium Metal Anodes with Three-Dimensional Lithium Hosts: Recent Progress and Future Perspectives

Batteries, 2023
Li metal has emerged as a promising anode material for high energy density batteries, due to its low electrochemical potential and high specific capacity of 3860 mAh·g−1.
Lina Chen, Haipeng Liu, Mengrui Li, Shiqiang Zhou, Funian Mo, Suzhu Yu, Jun Wei   +6 more
doaj   +1 more source