Results 41 to 50 of about 85,735 (301)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Self-assembly growth of electrolytic silver dendrites

Scientific Reports, 2022
The atomic level assembly of silver dendrite has never been disclosed despite the numerous studies published on fractal dendrite structures. We report for the first time an HRTEM investigation of the formation of atomic embryos (
Wen-Chieh Tsai, Kwang-Lung Lin
doaj   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Crossover Scaling in Dendritic Evolution at Low Undercooling

, 1999
We examine scaling in two-dimensional simulations of dendritic growth at low undercooling, as well as in three-dimensional pivalic acid dendrites grown on NASA's USMP-4 Isothermal Dendritic Growth Experiment.
A. A. Wheeler, A. A. Wheeler, A. Karma, Afina Lupulescu, D. A. Kessler, D. A. Kessler, E. Ben-Jacob, E. Brener, G. Caginalp, G. Caginalp, G. Caginalp, J. A. Warren, J. B. Collins, J. Ignés-Mullol, J. S. Langer, Jeffrey C. LaCombe, Jonathan Dantzig, K. R. Elder, M. B. Koss, M. E. Glicksman, M. E. Glicksman, M. Muschol, Martin E. Glicksman, Matthew B. Koss, N. Provatas, N. Provatas, N. Provatas, Nigel Goldenfeld, Nikolas Provatas, Q. Li, R. Almgren, R. Almgren, R. J. Braun, R. Kobayashi, Robert Almgren, S.-C. Huang, S.-L. Wang, U. Bisang, Y. Pomeau   +38 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Lithium dendrite inhibition effect induced by nucleation parameters based on the mechanical-thermo-electrochemical coupling model

iScience
Summary: Solid-state lithium batteries offer numerous advantages, including high energy density, superior mechanical strength, excellent cycle stability, non-flammability, and extended service life.
Wen-Qian Hao, Jia-Miao Xie, Peng-Yang Hou, Feng-Hui Wang   +3 more
doaj   +1 more source

Numerical Simulation of Three-Dimensional Dendrite Movement Based on the CA–LBM Method

Crystals, 2021
At present, the calculation of three-dimensional (3D) dendrite motion using the cellular automata (CA) method is still in its infancy. In this paper, a 3D dendrite motion model is constructed.
Qi Wang, Yingming Wang, Shijie Zhang, Binxu Guo, Chenyu Li, Ri Li   +5 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Understanding the formation of twinned dendrites (‘feather’ grains) [PDF]

, 2007
The phenomenon of feather grain growth is interesting from both a theoretical and commercial point of view. Here we report the results of phase-field simulations aimed at understanding the formation of twinned dendrites. We show that, while a competition
Mullis, A.M.
core