Results 61 to 70 of about 66,799 (292)

Comparative analysis of the Russian regions using machine learning methods for a set of indicators of electronic services

Цифровая социология
Digitalisation is important not only for the work of professionals in their workplaces, but also for the well-being of specialists and adaptation to changes in the information sphere as well as for providing high-quality educational, medical and social ...
L. A. Borisova
doaj   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

Study of biofilms by V. cholerae strains on the surfaces of biotic and abiotic substrates using mass spectrometry

Медицинский вестник Юга России, 2020
Objective: identification and comparative study of protein spectra of Vibrio cholerae biofilms by MALDI-ToF mass spectrometry.Materials and methods: V. cholerae O1 strains isolated from different sources were studied.
M. V. Poleeva, O. S. Chemisova, E. A. Menshikova, M. M. Sagakyants, E. M. Kurbatova   +4 more
doaj   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Utility of some floral characters in the assessment of genetic diversity in sesame (Sesamum indicum L.)

Acta Agriculturae Slovenica, 2017
Sesame collections were evaluated for quantitative floral characters and data obtained were subjected to various statistical analyses. Result showed narrow diversity in most of the quantitative floral characters with moderate variability in length of ...
Musibau Adewuyi Azeez, Modupe Bimpe Olowookere, David Adedayo Animasaun, Bashir Omolaran Bello   +3 more
doaj   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Method of verification of results of individual forecasting of products of radioelectronic facilities for space purposes with the help of cluster analysis algorithms

Физика волновых процессов и радиотехнические системы, 2017
The methodology and algorithm for obtaining verification results are proposed. The algorithm includes five steps: choice of parameters for cluster analysis algorithms, determination of the initial data by the results of the training experiment ...
R.O. Mishanov, M.N. Piganov
doaj  

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

Families of Dendrograms

, 2008
A conceptual framework for cluster analysis from the viewpoint of p-adic geometry is introduced by describing the space of all dendrograms for n datapoints and relating it to the moduli space of p-adic Riemannian spheres with punctures using a method recently applied by Murtagh (2004b).
openaire   +3 more sources

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source