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, 2016 Sympathetic nervous system over-activity is closely linked with elevation of systemic blood pressure. Both animal and human studies suggest renal sympathetic nerves play an important role in this respect. Historically, modulation of sympathetic activity has been used to treat hypertension. More recently, catheter based renal sympathetic denervation was
Mohammed Awais, Hameed +1 more
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Selective denervation of the heart
American Journal of Physiology-Heart and Circulatory Physiology, 1983 Total denervation of the canine heart consisted of intrapericardial neural dissection of the left atrium, left superior pulmonary vein, and main pulmonary artery and cutting of the ventrolateral cardiac nerve (stage I). The fat pad and all nerves were removed from between the pulmonary artery and aorta (stage II).
W C, Randall +3 more
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Scandinavian Journal of Plastic and Reconstructive Surgery, 1983
In a series of 48 painfully restricted wrists denervation was used during a 6-year period on wide indications as a surgical alternative. The observation time averaged 2.4 years. Pain relief occurred in 56% of the patients. Considering the simplicity of the method and the lack of serious complications, it is concluded that denervation of the wrist is ...
L, Ekerot, J, Holmberg, O, Eiken
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In a series of 48 painfully restricted wrists denervation was used during a 6-year period on wide indications as a surgical alternative. The observation time averaged 2.4 years. Pain relief occurred in 56% of the patients. Considering the simplicity of the method and the lack of serious complications, it is concluded that denervation of the wrist is ...
L, Ekerot, J, Holmberg, O, Eiken
openaire +2 more sources
American Journal of Kidney Diseases, 2022
Uncontrolled hypertension persists as an important health issue despite the availability of many medications and nondrug therapies that lower blood pressure. Increasingly, nonadherence to medication is found in approximately 2 of every 5 patients with uncontrolled hypertension.
Jimena, Rey-García, Raymond R, Townsend
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Uncontrolled hypertension persists as an important health issue despite the availability of many medications and nondrug therapies that lower blood pressure. Increasingly, nonadherence to medication is found in approximately 2 of every 5 patients with uncontrolled hypertension.
Jimena, Rey-García, Raymond R, Townsend
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European Journal of Internal Medicine, 2015
Renal denervation (RDN) has, within recent years, been suggested as a novel treatment option for patients with resistant hypertension. This review summarizes the current knowledge on this procedure as well as limitations and questions that remain to be answered.The Symplicity HTN-1 (2009) and HTN-2 (2010) studies re-introduced an old treatment approach
Lene Kjær Olsen +3 more
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Renal denervation (RDN) has, within recent years, been suggested as a novel treatment option for patients with resistant hypertension. This review summarizes the current knowledge on this procedure as well as limitations and questions that remain to be answered.The Symplicity HTN-1 (2009) and HTN-2 (2010) studies re-introduced an old treatment approach
Lene Kjær Olsen +3 more
openaire +3 more sources
Mechanisms of denervation supersensitivity in regionally denervated canine hearts
American Journal of Physiology-Heart and Circulatory Physiology, 1993Mechanisms responsible for “denervation supersensitivity” in regionally denervated canine hearts were examined by measuring beta-adrenergic receptor density and affinity and the density of the alpha-subunit of the stimulatory G protein (Gs alpha). Sympathetic denervation was produced by applying an epicardial strip of phenol midway between the left ...
M R, Warner +4 more
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Denervation-induced alterations of acetylcholinesterase in denervated and nondenervated muscle
Experimental Neurology, 1990The influence of denervation on acetylcholinesterase (AchE) molecular forms in rat skeletal muscle for durations up to 30 days is examined in denervated anterior tibialis, the innervated contralateral muscle, and diaphragm. Denervated rats at a common age of 8.5 weeks are compared with age-matched, nondenervated animals.
M M, Decker, H A, Berman
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