Results 101 to 110 of about 297,519 (217)

17‐epi‐Melianodiol, a new protolimonoid from Melia azedarach fruits, exhibits larvicidal activity and is associated with oxidative imbalance and midgut epithelial damage in Aedes aegypti larvae

Pest Management Science, Volume 82, Issue 9, Page 9240-9248, September 2026.
The bio‐guided phytochemical study resulted in the new compound 17‐epi‐melianodiol. The compound eliminated 100% of Aedes aegypti larvae at 100 ppm, causing pronounced morphological changes, cuticular damage, and extensive vacuolization. Abstract BACKGROUND In Brazil, Aedes aegypti is the primary vector of arboviruses such as dengue, chikungunya ...
Kethleen Duarte Crespo Soares, Thalya Soares Ribeiro Nogueira, Maria Aparecida Aride Bertonceli, Renata Rodrigues da Silva Robaina, Leticia Oliveira da Rocha, Francisco José Alves Lemos, Kátia Valevski Sales Fernandes, Raimundo Braz‐Filho, Ivo José Curcino Vieira   +8 more
wiley   +1 more source

Updates on Dengue Vaccines [PDF]

01-Dengue-chen-508 ...

core  

The Changing Landscape of Hantavirus Infections: A Narrative Review of Epidemiology, Pathogenesis, and Countermeasures

Reviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Hantaviruses are emerging zoonotic pathogens of increasing global public health significance. Their epidemiological landscape is rapidly changing due to ecological disruption, climate variability, urbanisation, and evolving human–animal interfaces.
Francesco De Maria, Francesco Branda, Giancarlo Ceccarelli, Fabio Scarpa, Massimo Ciccozzi, Alessandro Russo   +5 more
wiley   +1 more source

Current prevention and potential treatment options for dengue infection

Journal of Pharmacy & Pharmaceutical Sciences, 2019
Currently, treatments for dengue infection are only symptomatic as no antiviral agents nor vaccines are available to combat this virus. Despite challenges faced by researchers, many efforts are ongoing to reduce cases of dengue infection either by ...
Malina Jasamai, Wei Boon Yap, Aurapa Sakulpanich, Azmath Jaleel   +3 more
doaj   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

The role of antibody-dependent enhancement in dengue vaccination

Tropical Diseases, Travel Medicine and Vaccines
Dengue is the most rapidly spreading vector-borne disease worldwide, with over half the global population at risk for an infection. Antibody-dependent enhancement (ADE) is associated with increased disease severity and may also be attributable to the ...
D. G. Aynekulu Mersha, I. van der Sterren, L. P.M. van Leeuwen, T. Langerak, M. S. Hakim, B. Martina, S. F.L. van Lelyveld, E. C.M van Gorp   +7 more
doaj   +1 more source

Design and Synthesis of a Potent, Cell Active Purine‐Based Amidoxime Against the Dengue Virus

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
Scaffold hopping from our previous indolazepinone hit exemplifies purine SP‐835G with DENV2 EC50 0.1 µM, CC50>100 µM, clogP 3.61. Docking studies support its amidine metabolite operates as an allosteric inhibitor of DENV(pro). A flexible ether linker appears pivotal for enhancing binding and activity.
Dimitrios Kiousis, Despoina Giannioti, Georgia Kalyva, Vasiliki Zogali, Maharah Binte Abdul Mahid, Kitti Wing Ki Chan, Minos‐Timotheos Matsoukas, Subhash G. Vasudevan, Gerasimos Rassias   +8 more
wiley   +1 more source

Estimates of dengue force of infection in children in Colombo, Sri Lanka. [PDF]

, 2013
Dengue is the most important vector-borne viral disease worldwide and a major cause of childhood fever burden in Sri Lanka, which has experienced a number of large epidemics in the past decade.
Harold S Margolis, Margolis H.S., Aruna Dharshan De Silva (350174), Tam, Clarence C., Amarasinge, Ananda, Margolis, Harold S., de Silva A.D., de Silva, Aravinda M, Clarence C Tam, Harold S. Margolis (147272), Tissera, Hasitha, Aruna Dharshan De Silva, Aravinda M. de Silva (180486), de Silva, Aravinda M., Clarence C. Tam (378980), Hasitha Tissera (419200), Tam, Clarence C, Ananda Amarasinge (419201), Aravinda M de Silva, Tissera H., de Silva A.M., Amarasinge A., De Silva, Aruna Dharshan, Tam C.C., Hasitha Tissera, Ananda Amarasinge, Margolis, Harold S   +26 more
core   +2 more sources

Dengue vaccines: A new hope? [PDF]

Human Vaccines, 2009
Dengue infection is an important arboviral infection that has become a public health concern. Dengue vaccination is the expected primary prevention for this infection. However, dengue vaccine is not presently available. In this article, the author discusses and comments on the problem, hope and present status in dengue vaccine development.
openaire   +2 more sources

Climate Informed Dengue Prediction and Future Risk Under a Changing Monsoon Climate in Kerala, India

GeoHealth, Volume 10, Issue 9, September 2026.
Abstract Dengue fever has emerged as a major public health threat in India, with its burden projected to rise under climate change. This study investigates the influence of climate variability on dengue incidence in Kerala, a dengue hotspot in southern India, using 14 years of climate and dengue data (2006–2019).
Yacob Sophia, Mathew Koll Roxy, Surendranath Bindu Vaisakh, Pallipurathu Raghunathan Nair Sreelakshmi, Thekkumkara Surendran Anish, Pillaveetil Sathyadas Indu   +5 more
wiley   +1 more source