Results 101 to 110 of about 169,398 (330)

Optimization of 4‐Amino‐2‐Pyridone Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9: Integrating Structure–Activity and Structure–Metabolism Relationships

ChemMedChem, EarlyView.
Green chemistry‐based late‐stage functionalization (LSF) of the anti‐proprotein convertase subtilisin/kexin type 9 (PCSK9) early lead compound 5c led to optimized analogs with improved metabolic stability/PCSK9 IC50 ratio. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key drug target for the treatment of different hypercholesterolemia ...
Lisa Giannessi, Maria Giovanna Lupo, Martina Ugolotti, Bianca Papotti, Beatrice Mattina, Maria Grazia Martina, Anna Demurtas, Cristina Padula, Sara Nicoli, Marco Crescenzio, Nicola Ferri, Francesca Zimetti, Marco Radi   +12 more
wiley   +1 more source

Serotipe Virus Dengue Di Tiga Kabupaten/Kota Dengan Tingkat Endemisitas DBD Berbeda Di Propinsi Jawa Barat [PDF]

, 2010
. The incidence rate of Dengue Hemorrhagic Fever (DHF) disease in Indonesia is increas­ing over years. DHF outbreaks hap pen in many provinces of Indonesia. West Java is a DHF endemic province.
Astuti, E. P. (Endang), Prasetyowati, H. (Heni)   +1 more
core   +1 more source

Powerful yet challenging: mechanistic niche models for predicting invasive species potential distribution under climate change

Ecography, EarlyView.
Risk assessments of invasive species present one of the most challenging applications of species distribution models (SDMs) due to the fundamental issues of distributional disequilibrium, niche changes, and truncation. Invasive species often occupy only a fraction of their potential environmental and geographic ranges, as their spatiotemporal dynamics ...
Erola Fenollosa, Sean E. H. Pang, Natalie J. Briscoe, Antoine Guisan, Roberto Salguero-Gómez   +4 more
wiley   +1 more source

ヤマガタ ダイガク イガクブ フゾク ビョウイン ニオケル デングネツ ノ ソウキ ハッケン [PDF]

, 2005
Dengue fever (DF) is an acute febrile disease caused by dengue virus, which was re-emerged in tropical regions in the past 20 years. The numbers of imported DF were 6 to 44 per year in the recent Japan.
Harada Hiroko, Karube Hiroki, Tajima Katsushi   +2 more
core   +1 more source

TLR2 axis on peripheral blood mononuclear cells regulates inflammatory responses to circulating, non-infectious immature dengue virus particles [PDF]

, 2022
José A. Aguilar-Briseño, Lennon Ramos Pereira, Marleen van der Laan, Mindaugas Paužuolis, Bram M. ter Ellen, Vinit Upasani, Jill Moser, Luís Carlos de Souza Ferreira, Jolanda M. Smit, Izabela A. Rodenhuis‐Zybert   +9 more
openalex   +1 more source

Dengue Virus Infection in Africa

Emerging Infectious Diseases, 2011
Reported incidence of dengue has increased worldwide in recent decades, but little is known about its incidence in Africa. During 1960-2010, a total of 22 countries in Africa reported sporadic cases or outbreaks of dengue; 12 other countries in Africa reported dengue only in travelers.
Ananda Amarasinghe, Joel N. Kuritsky, G. William Letson, Harold S. Margolis   +3 more
openaire   +3 more sources

Triage and care for women with symptoms or diagnosis of pregnancy loss between 14 + 0 and 21 + 6 weeks' gestation

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Mid‐trimester pregnancy loss (MTL), defined as a pregnancy loss occurring between 14 + 0 and 21 + 6 weeks of gestation, causes significant physical and emotional distress to women and presents clinical challenges to healthcare professionals. It is acknowledged that in low‐resource settings, this guideline might be applicable to births up to 28 
Caroline E. Fox, Rosinder Kaur, Kugajeevan Vigneswaran, Rachel Small, Jenny Carter, Keelin O'Donoghue, Alexander E. P. Heazell, Anna L. David, Nigel Simpson, Angharad Care, Lisa Starrs, Andrew Shennan, Catalina María Valencia González, Priya Soma‐Pillay, Leah Fitzsimmons, Adam J. Devall, Arri Coomarasamy, Mid‐trimester Pregnancy Loss Guideline Consensus Panel, Owen Arthurs, Ruth Bender‐Atik, Phil Bennett, Kirstien Boelaert, Elizabeth Bonney, Leanna Brace, Naomi Carlisle, Davide Casagrandi, Manju Chandiramani, Carolyn Chiswick, Alexandra Emms, Stella Fielder, James Goadsby, Laura Goodfellow, Jim Gray, Jemma Johns, Emma Kirk, Will Lester, Sophie Mackay, Maria Memtsa, Katie Morris, Sunbal Mukhtar, Naimah Raza, Rita Sarquis, Neil Sebire, Lucy Smith, Lucy Spencer, Amos Tetteh, Natalie Woodhead   +46 more
wiley   +1 more source

Wolbachia wMel-mediated effects on dengue virus vertical transmission from Aedes aegypti to their offspring [PDF]

, 2023
Kien Duong Thi Hue, Daniela Gonçalves, Tran Thi Diem Thuy, Vo Thi Long, Le Thi Dui, Vu Thi Tuyet Nhu, Nguyen Thi Giang, Huynh Thi Xuan Trang, Nguyet Minh Nguyen, Nguyễn Thanh Phong, Sophie Yacoub, Cameron P. Simmons   +11 more
openalex   +1 more source

Dengue virus in Mexican bats

Epidemiology and Infection, 2008
SUMMARYIndividuals belonging to five families, 12 genera, and 19 different species of bats from dengue endemic areas in the Gulf and Pacific coasts of Mexico were examined by ELISA, RT–PCR, and for the presence of dengue virus (DV) NS1 protein. Nine individuals from four species were seropositive by ELISA: three insectivorous,Myotis nigricans(four ...
A, Aguilar-Setién, M L, Romero-Almaraz, C, Sánchez-Hernández, R, Figueroa, L P, Juárez-Palma, M M, García-Flores, C, Vázquez-Salinas, M, Salas-Rojas, A C, Hidalgo-Martínez, S Aguilar, Pierlé, C, García-Estrada, C, Ramos   +11 more
openaire   +3 more sources

Toward Dual‐Function Nanoparticle Platforms for Arboviral Diagnostics and Vaccines: Advances, Challenges, and Future Prospects

Nano Select, EarlyView.
This review explores nanoparticle (NP)‐based biosensors and nanovaccine platforms for arboviral infections, highlighting their design, performance, and translational potential. By comparing case studies across viruses, it identifies gold‐standard nanomaterials such as gold NPs (AuNPs), zinc oxide NPs (ZnONPs), molybdenum disulfide (MoS2) nanocomposites,
Peyman Halvaeikhanekahdani, Sajad Zandi, Qadeer Ahmad, Hadiseh Payravand   +3 more
wiley   +1 more source