Results 51 to 60 of about 1,017,177 (255)

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Corticosteroids for dengue - why don't they work? [PDF]

, 2013
BACKGROUND: Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS: In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47 ...
Tuan Trung Vu, Cameron P. Simmons, Thi Hanh, Simmons, Cameron, Simmons, C, Tuan Trung Vu (496520), Thi Hoai, Martin L. Hibberd, Wills, B, Nguyen, Than Ha Quyen, Whitehead, SS, Martin L Hibberd, Dong, TH, Vu, TT, Phung, Khanh Lam, Stephen S. Whitehead, Bridget Wills (74672), Khanh Lam Phung, Wills, Bridget, Thi Hanh Tien Nguyen, Quyen Nguyen, Phung, KL, Van Ngoc Tran, Tien Nguyen, Van Ngoc Tran (496523), Farrar, J, Ngoc Tran, Van, Farrar, Jeremy, Hoang, TL, Jeremy Farrar, Nguyen, TH, Ngoc Tran, V, Stephen S. Whitehead (150702), Dong, Thi Hoai Tam, Nguyen, Thi Hanh Tien, Than Ha Quyen Nguyen (496519), Wolbers, M, Thi Hoai Tam Dong (496522), Jeremy Farrar (74677), Vu, Tuan Trung, Simmons, CP, Thi Hoai Tam Dong, Tam Dong, Whitehead, Stephen S, Marcel Wolbers, Marcel Wolbers (33689), Simmons, Cameron P, Than Ha, Than Ha Quyen Nguyen, Stephen S Whitehead, Hibberd, ML, Wolbers, Marcel, Bridget Wills, Khanh Lam Phung (496524), Cameron P Simmons, Cameron P. Simmons (117211), Martin L. Hibberd (167212), Hoang, Truong Long, Hibberd, Martin L, Truong Long Hoang, Thi Hanh Tien Nguyen (496518), Truong Long Hoang (496521)   +61 more
core   +2 more sources

Seroprevalence of Dengue and Chikungunya Virus Antibodies, French Polynesia, 2014–2015

Emerging Infectious Diseases, 2018
We investigated dengue and chikungunya virus antibody seroprevalence in French Polynesia during 2014–2015. Dengue virus seroprevalence was ≈60% among schoolchildren and >83% among the general population; chikungunya virus seroprevalence was
Maite Aubry, Anita Teissier, Michael Huart, Sébastien Merceron, Jessica Vanhomwegen, Mihiau Mapotoeke, Teheipuaura Mariteragi-Helle, Claudine Roche, Anne-Laure Vial, Sylvianne Teururai, Sébastien Sicard, Sylvie Paulous, Philippe Desprès, Jean-Claude Manuguerra, Henri-Pierre Mallet, Allison Imrie, Didier Musso, Xavier Deparis, Van-Mai Cao-Lormeau   +18 more
doaj   +1 more source

Autophagy Activation Induces p62-Dependent Autophagic Degradation of Dengue Virus Capsid Protein During Infection

Frontiers in Microbiology, 2022
In the past decade, dengue virus infection is one of the most prevalent and rapidly spreading arthropod-borne diseases worldwide with about 400 million infections every year.
Yaoxing Wu, Tao Zhou, Jiajia Hu, Yishan Liu, Shouheng Jin, Jianfeng Wu, Xiangdong Guan, Jun Cui   +7 more
doaj   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

The monocyte-macrophage-mast cell axis in dengue pathogenesis

Journal of Biomedical Science, 2018
Dengue virus, the causative agent of dengue disease which may have hemorrhagic complications, poses a global health threat. Among the numerous target cells for dengue virus in humans are monocytes, macrophages and mast cells which are important ...
Shu-Wen Wan, Betty A. Wu-Hsieh, Yee-Shin Lin, Wen-Yu Chen, Yan Huang, Robert Anderson   +5 more
doaj   +1 more source

Association of Dengue Virus Serotypes 1&2 with Severe Dengue Having Deletions in Their 3′Untranslated Regions (3′UTRs)

Microorganisms, 2023
Dengue virus infections are recorded as hyper-endemic in many countries, including India. Research pertaining to the reasons for frequent outbreaks and severe dengue is ongoing.
Deepti Maisnam, Arcy Billoria, V. S. V Prasad, Musturi Venkataramana   +3 more
doaj   +1 more source

Models of dengue virus infection [PDF]

Drug Discovery Today: Disease Models, 2006
The need for models of dengue disease has reached a pinnacle as the transmission of this mosquito-borne virus has increased dramatically. Little is known about the mechanisms that lead to dengue fever and its more severe form, dengue hemorrhagic fever; this is owing to the fact that only humans show signs of disease.
Dennis A, Bente, Rebeca, Rico-Hesse
openaire   +2 more sources

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source