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Detection of Dengue Virus

2010
Global incidence of dengue has increased considerably over the past decade. Dengue fever (DF) is a self-limiting disease; however, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are fatal. Since there is no therapy and vaccine against dengue, timely diagnosis is therefore necessary for patient management. Laboratory diagnosis is carried
Ambuj Shrivastava   +3 more
openaire   +3 more sources

Behavior of the dengue virus in solution

Journal of Medical Virology, 2003
AbstractThe dengue virus consists of four antigenically related but distinct viruses, termed Dengue virus 1–4 (DEN 1–4). We have established that the dengue virus loses infectivity over time in solution in an exponentially declining manner. The four strains examined (one from each serotype) have half‐lives that range from 2.5 to 7.5 hr in defined ...
Chutima Thepparit   +3 more
openaire   +3 more sources

Discovery of Dengue Virus Inhibitors

Current Medicinal Chemistry, 2020
To date, there is still no approved anti-dengue agent to treat dengue infection in the market. Although the only licensed dengue vaccine, Dengvaxia is available, its protective efficacy against serotypes 1 and 2 of dengue virus was reported to be lower than serotypes 3 and 4.
Choon Han Heh   +9 more
openaire   +3 more sources

Dengue-2 virus in Kenya

The Lancet, 1990
No abstract ...
Hyams, KC.   +6 more
openaire   +3 more sources

Antibody response to dengue virus

Microbes and Infection, 2014
In this review, we discuss the current knowledge of the role of the antibody response against dengue virus and highlight novel insights into targets recognized by the human antibody response. We also discuss how the balance of pathological and protective antibody responses in the host critically influences clinical aspects of the disease.
Julio García-Cordero   +4 more
openaire   +3 more sources

Dengue Virus Vaccine Development

2014
Dengue virus (DENV) is a significant cause of morbidity and mortality in tropical and subtropical regions, causing hundreds of millions of infections each year. Infections range from asymptomatic to a self-limited febrile illness, dengue fever (DF), to the life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS).
Lauren E. Yauch, Sujan Shresta
openaire   +3 more sources

Reverse Genetics of Dengue Virus

2023
Dengue virus (DENV) is one of the most important and widespread arthropod-borne viruses, causing millions of infections over the years. Considering its epidemiological importance, efforts have been directed towards understanding various aspects of DENV biology, which have been facilitated by the development of different molecular strategies for ...
José Valter Joaquim, Silva Júnior   +3 more
openaire   +2 more sources

Virus Propagation and Plaque Assay for Dengue Virus

2021
This chapter describes the methods of propagation and titration for DENV-1 to -4, which are required for most of the experiments using live viruses. DENV does not reach titers as high as those of other viruses or as high as desired for their use in biological assays.
Pedro Henrique Carneiro   +2 more
openaire   +3 more sources

Adaptation of Dengue Virus to the Hamster

The American Journal of Tropical Medicine and Hygiene, 1952
Summary By serial intracerebral passages, the New Guinea C and Hawaiian strains of dengue virus were adapted to growth in hamsters of 2–5 days of age. Dengue virus should no longer be described, without qualification, as non-pathogenic for the hamster.
Edwin H. Lennette   +2 more
openaire   +3 more sources

Dengue Virus Diagnostics

2010
Dengue fever (DF) is an emerging arborviral disease caused by infection with dengue virus (DENV) which has emerged as the most important vector-borne viral disease in tropical areas and it continues to expand geographically. The four serotypes of DENV that cause human disease are transmitted by Aedes mosquitoes.
Robert S. Marks   +3 more
openaire   +2 more sources

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