Results 31 to 40 of about 495,147 (256)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark)

Scandinavian Journal of Work, Environment & Health, 2018
OBJECTIVE: The present study aims to assess if parental occupational exposure to solvents or heavy metals is associated with risk of testicular germ cell tumors (TGCT) in sons in Denmark.
Ann Olsson, Kayo Togawa, Joachim Schüz, Charlotte Le Cornet, Béatrice Fervers, Susanne Oksbjerg Dalton, Eero Pukkala, Maria Feychting, Niels Erik Skakkebæk, Johnni Hansen   +9 more
doaj   +1 more source

Expert-Led Securitization: The Case of the 2009 Pandemic in Denmark and Sweden

Politics and Governance, 2020
This article goes beyond the study of speech acts to investigate the process of securitization during a health crisis. The article introduces the concept of ‘expert-led securitization’ to account for situations when experts dominate the administrative ...
Olivier Rubin, Erik Baekkeskov
doaj   +1 more source

Diagnosing pancreatic cancer in general practice: a cross-sectional study on associations between suspicion of cancer, urgent referral and time to diagnosis

Scandinavian Journal of Primary Health Care, 2022
Objective This study aimed to investigate the first point of contact in patients diagnosed with pancreatic cancer, and to study factors associated with the GP’s suspicion of cancer, Cancer Patient Pathway (CPP) referral and long diagnostic interval ...
Line F. Virgilsen, Linda A. Rasmussen, Peter Vedsted, Henry Jensen   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Can beliefs about musculoskeletal pain and work be changed at the national level? Prospective evaluation of the Danish national Job & Body campaign

Scandinavian Journal of Work, Environment & Health, 2018
OBJECTIVES: This study evaluates the Danish national Job & Body campaign on beliefs about musculoskeletal pain and work. METHODS: Initiated in 2011, a national campaign in Denmark targeted public sector employees with a mixture of networking activities ...
Lars L Andersen, Niels Geisle, Brian Knudsen   +2 more
doaj   +1 more source

Vaccine Assemblages on Three HPV Vaccine-Critical Facebook Pages in Denmark from 2012 to 2019

Media and Communication, 2020
Misinformation about vaccines on social media is a growing concern among healthcare professionals, medical experts, and researchers. Although such concerns often relate to the total sum of information flows generated online by many groups of stakeholders,
Torben E. Agergaard, Màiri E. Smith, Kristian H. Nielsen   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Occupational history of night shift work and Parkinson’s disease in Denmark

Scandinavian Journal of Work, Environment & Health, 2015
OBJECTIVES: We investigated whether working night shifts was associated with the risk of Parkinson’s disease (PD). METHODS: Between January 2008 and December 2010, we recruited 1808 patients with a confirmed diagnosis of idiopathic PD from Denmark and ...
Eva S Schernhammer, Christina Funch Lassen, Line Kenborg, Beate Ritz, Jørgen H Olsen, Johnni Hansen   +5 more
doaj   +1 more source

Rekruttering af deltagere til online spørgeskemaundersøgelser om kriminelle aktiviteter

Nordisk Tidsskrift for Kriminalvidenskab, 2022
English abstract Internet-mediated research methods are increasingly used to access hidden crime-involved populations such as drug users and drug dealers.
Thomas Friis Søgaard, Nina Tvede Korshøj, Vibeke Asmussen Frank   +2 more
doaj   +1 more source