Results 41 to 50 of about 724,864 (273)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark)

open access: yesScandinavian Journal of Work, Environment & Health, 2018
OBJECTIVE: The present study aims to assess if parental occupational exposure to solvents or heavy metals is associated with risk of testicular germ cell tumors (TGCT) in sons in Denmark.
Ann Olsson   +9 more
doaj   +1 more source

Expert-Led Securitization: The Case of the 2009 Pandemic in Denmark and Sweden

open access: yesPolitics and Governance, 2020
This article goes beyond the study of speech acts to investigate the process of securitization during a health crisis. The article introduces the concept of ‘expert-led securitization’ to account for situations when experts dominate the administrative ...
Olivier Rubin, Erik Baekkeskov
doaj   +1 more source

Diagnosing pancreatic cancer in general practice: a cross-sectional study on associations between suspicion of cancer, urgent referral and time to diagnosis

open access: yesScandinavian Journal of Primary Health Care, 2022
Objective This study aimed to investigate the first point of contact in patients diagnosed with pancreatic cancer, and to study factors associated with the GP’s suspicion of cancer, Cancer Patient Pathway (CPP) referral and long diagnostic interval ...
Line F. Virgilsen   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Can beliefs about musculoskeletal pain and work be changed at the national level? Prospective evaluation of the Danish national Job & Body campaign

open access: yesScandinavian Journal of Work, Environment & Health, 2018
OBJECTIVES: This study evaluates the Danish national Job & Body campaign on beliefs about musculoskeletal pain and work. METHODS: Initiated in 2011, a national campaign in Denmark targeted public sector employees with a mixture of networking activities ...
Lars L Andersen   +2 more
doaj   +1 more source

Vaccine Assemblages on Three HPV Vaccine-Critical Facebook Pages in Denmark from 2012 to 2019

open access: yesMedia and Communication, 2020
Misinformation about vaccines on social media is a growing concern among healthcare professionals, medical experts, and researchers. Although such concerns often relate to the total sum of information flows generated online by many groups of stakeholders,
Torben E. Agergaard   +2 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

open access: yesFEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley   +5 more
wiley   +1 more source

Occupational history of night shift work and Parkinson’s disease in Denmark

open access: yesScandinavian Journal of Work, Environment & Health, 2015
OBJECTIVES: We investigated whether working night shifts was associated with the risk of Parkinson’s disease (PD). METHODS: Between January 2008 and December 2010, we recruited 1808 patients with a confirmed diagnosis of idiopathic PD from Denmark and ...
Eva S Schernhammer   +5 more
doaj   +1 more source

Rekruttering af deltagere til online spørgeskemaundersøgelser om kriminelle aktiviteter

open access: yesNordisk Tidsskrift for Kriminalvidenskab, 2022
English abstract Internet-mediated research methods are increasingly used to access hidden crime-involved populations such as drug users and drug dealers.
Thomas Friis Søgaard   +2 more
doaj   +1 more source

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