Results 241 to 250 of about 7,500 (302)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Navigating ethical minefields: a multi-stakeholder approach to assessing interconnected risks in generative AI using grey DEMATEL. [PDF]

Front Artif Intell
Jonnala S, Thomas NM, Mishra S.
europepmc   +1 more source

Physeal effects of posterior VBT are not uniform throughout a multi-tether construct in the kyphotic swine model. [PDF]

Spine Deform
Halanski MA, Kokinos B, Jeffers C, Crenshaw T.   +3 more
europepmc   +1 more source

Ex vivo model for assessing fetal membrane integrity and therapeutic strategies. [PDF]

Sci Rep
Moser L, Tschan B, Gegenschatz-Schmid K, Robmann S, Jacobs M, Odabasi R, Ochsenbein-Kölble N, Ehrbar M.   +7 more
europepmc   +1 more source

Enhancement of plant growth in lentil (Lens culinaris) under salinity stress by exogenous application or seed priming with salicylic acid and hydrogen peroxide. [PDF]

PLoS One
Bouallegue A, Horchani F, Souissi F, Tebini M, Jalali K, Ahmed HB, Abbes Z, Mhadhbi H.   +7 more
europepmc   +1 more source

A Proposal for Terminology for Clear Communication and Avoidance of Confusion in Relation to Sex, the Social Expectations of the Sexes and Gender Identity. [PDF]

Arch Sex Behav
Gribble KD.
europepmc   +1 more source

Amplifying metabolic profiling of extracellular vesicle dynamics with ACTIVITY. [PDF]

Nat Commun
Yu RJ, Ma WY, Xiao HY, Zhang YW, Gong WB, Yu ZF, Wei KL, Xing KR, Wang X, Zhu HJ, Wang LH, Ding XG.   +11 more
europepmc   +1 more source

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Denotation of Dyspnea

JAMA: The Journal of the American Medical Association, 1978
To the Editor.— The use of the word "dyspnea" by Thomas A. Raffin, MD, and James Theodore, MD, in their discussion in CLINICAL CARDIOLOGY "Separating Cardiac From Pulmonary Dyspnea" (238:2066, 1977), disturbed me. They carefully defined the word as "an uncomfortable awareness of the act of breathing, leading to a sensation most conveniently described ...
openaire   +4 more sources

WHY DENOTATIONAL?

Fundamenta Informaticae, 1996
This is an essay where the author expresses his views on applied denotational semantics. In the author's opinion, whether a software system has or does not have a sufficiently abstract denotational semantics should be regarded as a pragmatic attribute of the system rather than merely as a mathematical attribute of its description.
openaire   +3 more sources