Results 91 to 100 of about 3,321,801 (325)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Comparison of the diagnostic performance of Quantra artificial intelligence software with an experienced radiologist in the mammographic breast density assessment in women with and without breast implants

Journal of the Mexican Federation of Radiology and Imaging
Mammographic sensitivity decreases when mammographic breast density (MBD) is assessed in women with dense breasts and/or breast implants. This study compared the diagnostic performance of Quantra artificial intelligence (AI) software with an experienced ...
Beatriz E. Gonzalez-Ulloa, Claudia B. Corona-Gonzalez, Rosa L. Molina-Gutierrez   +2 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

A tumor specific antibody to aid breast cancer screening in women with dense breast tissue

Genes & cancer, 2017
Screening for breast cancer has predominantly been done using mammography. Unfortunately, mammograms miss 50% cancers in women with dense breast tissue. Multi-modal screenings offer the best chance of enhancing breast cancer screening effectiveness.
Lopamudra D. Roy, Lloye M. Dillon, Ru Zhou, L. J. Moore, C. Livasy, J. El-Khoury, R. Puri, P. Mukherjee   +7 more
semanticscholar   +1 more source

Comparison of Abbreviated Breast MRI vs Digital Breast Tomosynthesis for Breast Cancer Detection Among Women with Dense Breasts Undergoing Screening

Journal of the American Medical Association (JAMA), 2020
Importance: Improved screening methods for women with dense breasts are needed because of their increased risk of breast cancer and of failed early diagnosis by screening mammography.
C. Comstock, C. Gatsonis, G. Newstead, B.S. Snyder, Ilana F. Gareen, Jennifer T Bergin, Habib Rahbar, Janice S. Sung, Christina Jacobs, J. Harvey, Mary H Nicholson, R. C. Ward, Jacqueline Holt, Andrew Prather, K. Miller, M. Schnall, C. Kuhl   +16 more
semanticscholar   +1 more source

Optimal Screening in Breast Cancer Survivors With Dense Breasts on Mammography

Journal of Clinical Oncology, 2020
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches.
Habib, Rahbar, Janie M, Lee, Christoph I, Lee   +2 more
openaire   +3 more sources

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

The mammographically dense breast : strategies in breast cancer imaging [PDF]

, 2016
W e have known for some time that a dense breast on mammography presents diagnostic problems in the detection of breast cancer. It has also been suggested that women with dense breasts are at a higher risk for developing breast cancer.
Vassallo, Pierre
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