Results 1 to 10 of about 1,026 (108)

Microdialysis in Peripheral Tissues

Advanced Drug Delivery Reviews, 2000
The objective of this review is to survey the recent literature regarding the applications of microdialysis in pharmacokinetic studies and facilitating many other studies in peripheral tissues such as muscle, subcutaneous adipose tissue, heart, lung, etc.
Hartmut Derendorf
exaly   +4 more sources

Tibial bone and soft-tissue concentrations following combination therapy with vancomycin and meropenem – evaluated by microdialysis in a porcine model should patients with open fractures have higher doses of antibiotics?

Bone & Joint Research, 2022
Aims Prompt and sufficient broad-spectrum empirical antibiotic treatment is key to preventing infection following open tibial fractures. Succeeding co-administration, we dynamically assessed the time for which vancomycin and meropenem concentrations were
Sofus Ørbæk Vittrup, Pelle Hanberg, Martin Bruun Knudsen, Sara Kousgaard Tøstesen, Josephine Olsen Kipp, Jakob Hansen, Nis Pedersen Jørgensen, Maiken Stilling, Mats Bue   +8 more
doaj   +1 more source

Subtherapeutic levels of cefuroxime inside a cannulated pedicle screw used in spine surgery: results from a porcine microdialysis study

Acta Orthopaedica, 2022
Background and purpose: Minimally invasive spine surgery has continuously evolved for specific surgical procedures and patient populations to lower morbidity and the risk of postoperative bacterial infection.
Magnus A Hvistendahl, Pelle Hanberg, Maiken Stilling, Alexander Emil Kaspersen, Kristian Høy, Mats Bue   +5 more
doaj   +1 more source

High Cefuroxime Concentrations and Long Elimination in an Orthopaedic Surgical Deadspace—A Microdialysis Porcine Study

Antibiotics, 2022
Deadspace is the tissue and bony defect in a surgical wound after closure. This space is presumably poorly perfused favouring bacterial proliferation and biofilm formation.
Sara Kousgaard Tøstesen, Maiken Stilling, Pelle Hanberg, Theis Muncholm Thillemann, Thomas Falstie-Jensen, Mikkel Tøttrup, Martin Knudsen, Emil Toft Petersen, Mats Bue   +8 more
doaj   +1 more source

Effects of tourniquet inflation on peri- and postoperative cefuroxime concentrations in bone and tissue

Acta Orthopaedica, 2021
Background and purpose — Tourniquet is widely used in orthopedic surgery to reduce intraoperative bleeding and improve visualization. We evaluated the effect of tourniquet application on peri- and postoperative cefuroxime concentrations in subcutaneous ...
Pelle Hanberg, Mats Bue, Jesper Kabel, Andrea René Jørgensen, Christian Jessen, Kjeld Søballe, Maiken Stilling   +6 more
doaj   +1 more source

Overview of Microdialysis [PDF]

Current Protocols in Neuroscience, 1997
AbstractThe technique of microdialysis enables the monitoring of neurotransmitters and other molecules in the extracellular environment. This method has undergone several modifications and is now widely used for sampling and quantitating neurotransmitters, neuropeptides, and hormones in the brain and periphery.
T S, Shippenberg, A C, Thompson
openaire   +2 more sources

Microdialysis in Rodents [PDF]

Current Protocols in Neuroscience, 2009
AbstractMicrodialysis is an in vivo sampling technique that permits the quantification of various substances (e.g., neurotransmitters, peptides, electrolytes) in blood and tissue. It is also used to infuse substances into the brain and spinal cord. This unit describes methods for the construction and stereotaxic implantation of microdialysis probes ...
Agustin, Zapata, Vladimir I, Chefer, Toni S, Shippenberg   +2 more
openaire   +2 more sources

Technical notes on the placement of cerebral microdialysis: A single center experience

Frontiers in Neurology, 2023
BackgroundCerebral microdialysis enables monitoring of brain metabolism and can be an important part of multimodal monitoring strategies in a variety of brain injuries.
Joseph A. Falcone, Jefferson W. Chen
doaj   +1 more source

Comparison of Intravenous Microdialysis and Standard Plasma Sampling for Monitoring of Vancomycin and Meropenem Plasma Concentrations—An Experimental Porcine Study

Antibiotics, 2023
Microdialysis is a catheter-based method suitable for dynamic sampling of unbound antibiotic concentrations. Intravenous antibiotic concentration sampling by microdialysis has several advantages and may be a superior alternative to standard plasma ...
Johanne Gade Lilleøre, Sofus Vittrup, Sara Kousgaard Tøstesen, Pelle Hanberg, Maiken Stilling, Mats Bue   +5 more
doaj   +1 more source

Monitoring of patients with microdialysis following pancreaticoduodenectomy—the MINIMUM study: study protocol for a randomized controlled trial

Trials, 2021
Background Postoperative pancreatic fistula after pancreatoduodenectomy is a much-feared complication associated with substantial mortality and morbidity.
Espen Lindholm, Nil Ekiz, Tor Inge Tønnessen   +2 more
doaj   +1 more source