Results 1 to 10 of about 58,170 (269)

Sampling insulin in different tissue compartments using microdialysis: methodological aspects [PDF]

Scientific Reports, 2020
Sampling the concentration of insulin in human skin using microdialysis is challenging because of low intracutaneous concentrations and low recovery, presumably due to adsorption of insulin to the microdialysis system.
Alexandra Högstedt, Bijar Ghafouri, Erik Tesselaar, Simon Farnebo   +3 more
doaj   +2 more sources

Fat Oxidation, But Not Subcutaneous Adipose Tissue Lipolysis, Differs Between Males and Females During a Treadmill-Based Heat Tolerance Test. [PDF]

Eur J Sport Sci
ABSTRACT This study aimed to determine whether fat metabolism differs between males and females when exposed to extreme exercise‐heat stress. Physically active males (n = 11, 23 ± 4 years, 81.7 ± 11.8 kg, body fat 16.4 ± 6.6%) and females (n = 13, 25 ± 4 years, 60.4 ± 7.1 kg, 24.4 ± 6.7%) completed a 2‐h exercise‐heat tolerance test (40° $\boldsymbol{{}
Morrissey-Basler MC, Szymanski MR, Filep EM, Langan SP, Ormsbee MJ, Lee EC, Casa DJ.   +6 more
europepmc   +2 more sources

Microdialysis on Ex Vivo Porcine Ear Skin Can Validly Study Dermal Penetration including the Fraction of Transfollicular Penetration—Demonstrated on Caffeine Nanocrystals [PDF]

Nanomaterials, 2021
Common ex vivo methods for penetration investigations often fail to monitor transfollicular penetration appropriately. In the present investigation, the validity of dermal microdialysis on the ex vivo porcine ear skin to investigate penetration kinetics,
Anna Lena Klein, Markus Lubda, David Specht, Sung-Min Pyo, Loris Busch, Jürgen Lademann, Martina C. Meinke, Ingeborg Beckers, Jörg von Hagen, Cornelia M. Keck, Alexa Patzelt   +10 more
doaj   +2 more sources

A human-scale porcine fasciocutaneous and muscle flap model for the evaluation of ortho-plastic reconstructions of lower-limb defects [PDF]

Journal of Bone and Joint Infection
Introduction: Fasciocutaneous and muscle flaps are used for the reconstruction of lower-limb composite bone and soft-tissue defects. Flap-mediated contributions to the healing microenvironment are less described.
J. Slater, J. Slater, M. Stilling, M. Stilling, M. Stilling, A. E. Krag, A. E. Krag, A. E. Krag, S. K. Tøstesen, S. K. Tøstesen, M. K. D. Mikkelsen, M. K. D. Mikkelsen, M. McNally, A. J. Ramsden, L. K. Jensen, B. J. Kiil, M. Bue, M. Bue, M. Bue   +18 more
doaj   +2 more sources

CarboCell G/C offers high and prolonged concentrations of gentamicin and clindamycin in bone tissue following intraosseous injection [PDF]

Journal of Bone and Joint Infection
Objectives: The novel local antibiotic-eluting depot technology CarboCell G/C has shown great promise in terms of efficacy in an osteomyelitis pig model.
M. K. D. Mikkelsen, M. K. D. Mikkelsen, A. R. Jørgensen, N. G. Kotla, M. Stilling, M. Stilling, M. Stilling, M. B. Damsgaard, M. B. Damsgaard, C. Crocoll, M. Poborsky, H. C. Rasmussen, J. R. Henriksen, A. E. Hansen, M. Bue, M. Bue, M. Bue   +16 more
doaj   +2 more sources

Cerebral microdialysis [PDF]

Journal of Neuroanaesthesiology and Critical Care, 2015
Cerebral microdialysis is one of the latest neuromonitoring modalities introduced to clinical practice. It is a bedside monitor used to assess brain tissue biochemistry. The principle of this technique is closely related to brain metabolism and dialysis.
Charu Mahajan, Girija P Rath
doaj   +2 more sources

Microdialysis in peripheral tissues

Advanced Drug Delivery Reviews, 2000
The objective of this review is to survey the recent literature regarding the applications of microdialysis in pharmacokinetic studies and facilitating many other studies in peripheral tissues such as muscle, subcutaneous adipose tissue, heart, lung, etc.
Ping Liu, Hartmut Derendorf
exaly   +4 more sources

Detection of Neuronal Glutamate in Brain Extracellular Space In Vivo Using Microdialysis and Metabolic Labeling with Glutamine. [PDF]

ACS Chem Neurosci
Hershey ND, Popov P, Oliver NM, Dugan CE, Kennedy RT.   +4 more
europepmc   +3 more sources

Tibial bone and soft-tissue concentrations following combination therapy with vancomycin and meropenem – evaluated by microdialysis in a porcine model should patients with open fractures have higher doses of antibiotics?

Bone & Joint Research, 2022
Aims Prompt and sufficient broad-spectrum empirical antibiotic treatment is key to preventing infection following open tibial fractures. Succeeding co-administration, we dynamically assessed the time for which vancomycin and meropenem concentrations were
Sofus Ørbæk Vittrup, Pelle Hanberg, Martin Bruun Knudsen, Sara Kousgaard Tøstesen, Josephine Olsen Kipp, Jakob Hansen, Nis Pedersen Jørgensen, Maiken Stilling, Mats Bue   +8 more
doaj   +1 more source

Subtherapeutic levels of cefuroxime inside a cannulated pedicle screw used in spine surgery: results from a porcine microdialysis study

Acta Orthopaedica, 2022
Background and purpose: Minimally invasive spine surgery has continuously evolved for specific surgical procedures and patient populations to lower morbidity and the risk of postoperative bacterial infection.
Magnus A Hvistendahl, Pelle Hanberg, Maiken Stilling, Alexander Emil Kaspersen, Kristian Høy, Mats Bue   +5 more
doaj   +1 more source