Results 21 to 30 of about 34,690 (216)

CarboCell G/C offers high and prolonged concentrations of gentamicin and clindamycin in bone tissue following intraosseous injection [PDF]

Journal of Bone and Joint Infection
Objectives: The novel local antibiotic-eluting depot technology CarboCell G/C has shown great promise in terms of efficacy in an osteomyelitis pig model.
M. K. D. Mikkelsen, M. K. D. Mikkelsen, A. R. Jørgensen, N. G. Kotla, M. Stilling, M. Stilling, M. Stilling, M. B. Damsgaard, M. B. Damsgaard, C. Crocoll, M. Poborsky, H. C. Rasmussen, J. R. Henriksen, A. E. Hansen, M. Bue, M. Bue, M. Bue   +16 more
doaj   +1 more source

Evidence for Dysfunction of the Nigrostriatal Pathway in the R6/1 Line of Transgenic Huntington's Disease Mice

Neurobiology of Disease, 2002
The present multidisciplinary study examined nigrostriatal dopamine and striatal amino acid transmission in the R6/1 line of transgenic Huntington's disease (HD) mice expressing exon 1 of the HD gene with 115 CAG repeats.
Å. Petersén, Z. Puschban, J. Lotharius, B. NicNiocaill, P. Wiekop, W.T. O'Connor, P. Brundin   +6 more
doaj   +1 more source

Simultaneous blood and brain microdialysis in a free-moving mouse to test blood-brain barrier permeability of chemicals

Toxicology Reports, 2020
Neurotoxic chemicals that pass through the blood-brain barrier (BBB) can influence brain function. Efficient methods to test the permeability of the BBB to specific chemicals would facilitate identification of potentially neurotoxic agents.
Toyoshi Umezu, Tomoharu Sano, Junko Hayashi, Yasuyuki Shibata   +3 more
doaj   +1 more source

Enhanced human tissue microdialysis using hydroxypropyl-ß-cyclodextrin as molecular carrier. [PDF]

PLoS ONE, 2013
Microdialysis sampling of lipophilic molecules in human tissues is challenging because protein binding and adhesion to the membrane limit recovery.
Marcus May, Sandor Batkai, Alexander A Zoerner, Dimitrios Tsikas, Jens Jordan, Stefan Engeli   +5 more
doaj   +1 more source

Bedside interpretation of cerebral energy metabolism utilizing microdialysis in neurosurgical and general intensive care

Frontiers in Neurology, 2022
The microdialysis technique was initially developed for monitoring neurotransmitters in animals. In 1995 the technique was adopted to clinical use and bedside enzymatic analysis of glucose, pyruvate, lactate, glutamate and glycerol.
Carl-Henrik Nordström, Axel Forsse, Rasmus Peter Jakobsen, Simon Mölström, Troels Halfeldt Nielsen, Palle Toft, Urban Ungerstedt   +6 more
doaj   +1 more source

Increased Levels of Glutamate in Patients with Subarachnoid Haemorrhage as Measured by Intracerebral Microdialysis

, 1996
Cerebral ischemia associated with subarachnoid haemorrhage (SAH) may have severe consequences for neuronal function leading to reversible or permanent neurological deficits.
Säveland, H.,, Wieloch, T.,, Brandt, Lennart,, Nilsson, O. G.,, Lund University., Boris-Möller, F.,   +5 more
core   +2 more sources

A human-scale porcine fasciocutaneous and muscle flap model for the evaluation of ortho-plastic reconstructions of lower-limb defects [PDF]

Journal of Bone and Joint Infection
Introduction: Fasciocutaneous and muscle flaps are used for the reconstruction of lower-limb composite bone and soft-tissue defects. Flap-mediated contributions to the healing microenvironment are less described.
J. Slater, J. Slater, M. Stilling, M. Stilling, M. Stilling, A. E. Krag, A. E. Krag, A. E. Krag, S. K. Tøstesen, S. K. Tøstesen, M. K. D. Mikkelsen, M. K. D. Mikkelsen, M. McNally, A. J. Ramsden, L. K. Jensen, B. J. Kiil, M. Bue, M. Bue, M. Bue   +18 more
doaj   +1 more source

Modeling the measurement bias in interstitial glucose concentrations derived from microdialysis in skeletal muscle

Physiological Reports, 2022
Muscle tissue utilizes glucose as a fuel during exercise and stores glucose in form of glycogen during rest. The associated glucose transport includes delivery of glucose from blood plasma into the interstitial space and subsequent, GLUT‐4 facilitated ...
Hugo Angleys, Leif Østergaard
doaj   +1 more source

Evaluation of intramuscular lateral distribution profile of topically administered acetaminophen in rats [PDF]

, 2007
To clarify to what extent topically administered drug molecules horizontally permeate into tissues surrounding the administration site, the intramuscular lateral concentration profile of acetaminophen was investigated in vivo using the ...
A OMOTO, Tagawa, Masahiro, Omoto, Akiho, M TAGAWA, T AIBA, Y KOMORI, Kawasaki, Hiromu, Suito, Hiroshi, Komori, Yukiko, Y KUROSAKI, H KAWASAKI, Kurosaki, Yuji, Aiba, Tetsuya, H SUITO   +13 more
core   +1 more source

Proteomic analysis of interstitial fluid for novel markers of the cutaneous response to injury [PDF]

, 2009
The inflammatory response is critical to healing outcome after cutaneous injury. Our current understanding of the response to injury has been compiled from targeted studies on components expected to play a role.
Gill, Carolyn Anne
core   +1 more source