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An overview of clinical cerebral microdialysis in acute brain injury [PDF]

Frontiers in Neurology, 2023
Cerebral microdialysis may be used in patients with severe brain injury to monitor their cerebral physiology. In this article we provide a concise synopsis with illustrations and original images of catheter types, their structure, and how they function ...
Matthew G. Stovell, Matthew G. Stovell, Adel Helmy, Eric P. Thelin, Eric P. Thelin, Ibrahim Jalloh, Peter J. Hutchinson, Peter J. Hutchinson, Keri L. H. Carpenter, Keri L. H. Carpenter   +9 more
doaj   +4 more sources

Technical notes on the placement of cerebral microdialysis: A single center experience [PDF]

Frontiers in Neurology, 2023
BackgroundCerebral microdialysis enables monitoring of brain metabolism and can be an important part of multimodal monitoring strategies in a variety of brain injuries.
Joseph A. Falcone, Jefferson W. Chen
doaj   +4 more sources

Experimental Insights and Recommendations for Successfully Performing Cerebral Microdialysis With Hydrophobic Drug Candidates [PDF]

Clinical and Translational Science
Cerebral microdialysis in rodents represents a robust and versatile technique for quantifying the pharmacologically relevant unbound fraction of drugs in the brain.
Julia K. Sundheimer, Julia Benzel, Rémi Longuespée, Jürgen Burhenne, Stefan M. Pfister, Kendra K. Maaß, Max Sauter, Kristian W. Pajtler   +7 more
doaj   +3 more sources

Editorial: Cerebral microdialysis [PDF]

Frontiers in Neurology, 2023
Jefferson W. Chen, Alex B. Valadka, M. Ross Bullock, Keri L. H. Carpenter   +3 more
doaj   +4 more sources

Clinical Use of Cerebral Microdialysis in Patients with Aneurysmal Subarachnoid Hemorrhage—State of the Art [PDF]

Frontiers in Neurology, 2017
ObjectiveTo review the published literature on the clinical application of cerebral microdialysis (CMD) in aneurysmal subarachnoid hemorrhage (SAH) patients and to summarize the evidence relating cerebral metabolism to pathophysiology, secondary brain ...
Raimund Helbok, Mario Kofler, Alois Josef Schiefecker, Maxime Gaasch, Verena Rass, Bettina Pfausler, Ronny Beer, Erich Schmutzhard   +7 more
doaj   +4 more sources

Cerebral microdialysis and glucopenia in traumatic brain injury: A review [PDF]

Frontiers in Neurology, 2023
Traditionally, intracranial pressure (ICP) and partial brain tissue oxygenation (PbtO2) have been the primary invasive intracranial measurements used to guide management in patients with severe traumatic brain injury (TBI).
Himanshu Sharma, John P. McGinnis, Katherine E. Kabotyanski, Shankar P. Gopinath, Jerry C. Goodman, Claudia Robertson, Jovany Cruz Navarro, Jovany Cruz Navarro   +7 more
doaj   +2 more sources

Correlation of Cerebral Microdialysis with Non-Invasive Diffuse Optical Cerebral Hemodynamic Monitoring during Deep Hypothermic Cardiopulmonary Bypass [PDF]

Metabolites, 2022
Neonates undergoing cardiac surgery involving aortic arch reconstruction are at an increased risk for hypoxic-ischemic brain injury. Deep hypothermia is utilized to help mitigate this risk when periods of circulatory arrest are needed for surgical repair.
Tiffany S. Ko, Constantine D. Mavroudis, Emilie J. Benson, Rodrigo M. Forti, Richard W. Melchior, Timothy W. Boorady, Vincent C. Morano, Kobina Mensah-Brown, Yuxi Lin, Danielle Aronowitz, Jonathan P. Starr, Tami M. Rosenthal, Brandon C. Shade, Kellie L. Schiavo, Brian R. White, Jennifer M. Lynch, J. William Gaynor, Daniel J. Licht, Arjun G. Yodh, Wesley B. Baker, Todd J. Kilbaugh   +20 more
doaj   +2 more sources

Ethyl Pyruvate Increases Post-Ischemic Levels of Mitochondrial Energy Metabolites: A ¹³C-Labeled Cerebral Microdialysis Study [PDF]

Metabolites, 2020
Mitochondrial dysfunction after transient cerebral ischemia can be monitored by cerebral microdialysis (CMD) using changes in the lactate and pyruvate concentrations and ratio.
Kevin H. Nygaard, Jesper F. Havelund, Troels H. Nielsen, Carl-Henrik Nordström, Nils. J. Færgeman, Frantz R. Poulsen, Jan Bert Gramsbergen, Axel Forsse   +7 more
doaj   +2 more sources

Bedside interpretation of cerebral energy metabolism utilizing microdialysis in neurosurgical and general intensive care

Frontiers in Neurology, 2022
The microdialysis technique was initially developed for monitoring neurotransmitters in animals. In 1995 the technique was adopted to clinical use and bedside enzymatic analysis of glucose, pyruvate, lactate, glutamate and glycerol.
Carl-Henrik Nordström, Axel Forsse, Rasmus Peter Jakobsen, Simon Mölström, Troels Halfeldt Nielsen, Palle Toft, Urban Ungerstedt   +6 more
doaj   +3 more sources

Defining metabolic abnormalities in acute human traumatic brain injury with cerebral microdialysis and multimodality monitoring. [PDF]

PLoS ONE
ObjectiveWe aimed to compare the prevalence and multimodal associations of mitochondrial dysfunction as defined by published cerebral-microdialysis-based criteria versus our novel multimodality-monitoring-based criteria in acute traumatic brain injury ...
Michael S Baker, Sara Venturini, Caroline Lindblad, Joshua M Heihre, Ivan Timofeev, Mathew R Guilfoyle, Peter J Hutchinson, Keri L H Carpenter, Adel Helmy   +8 more
doaj   +2 more sources