Journal of Neuroanaesthesiology and Critical Care, 2015 Cerebral microdialysis is one of the latest neuromonitoring modalities introduced to clinical practice. It is a bedside monitor used to assess brain tissue biochemistry. The principle of this technique is closely related to brain metabolism and dialysis.
Charu Mahajan, Girija P Rath
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Indian Journal of Neurosurgery, 2017 Patients with traumatic brain injury (TBI) have variable outcomes subject to intracranial hypertension, ischemia, hypotension, and various biochemical alterations.
Deepak Kumar Gupta, Anna Teresa Mazzeo
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Cerebral Microdialysis in Aneurismal Subarachnoid Hemorrhage Patient Reveals a Detrimental Shift in Brain Energy Metabolism, Despite Normal Perfusion Pressure [PDF]
Metabolites, 2020 The present case study concerns a patient admitted to our neuro-intensive care unit with a severe aneurismal subarachnoid hemorrhage rebleeding. The patient was equipped with multimodal neuromonitoring, including cerebral microdialysis.
Frederik Nielsen +4 more
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Investigating the Central Nervous System Disposition of Actinomycin D: Implementation and Evaluation of Cerebral Microdialysis and Brain Tissue Measurements Supported by UPLC-MS/MS Quantification [PDF]
Pharmaceutics, 2021 Actinomycin D is a potent cytotoxic drug against pediatric (and other) tumors that is thought to barely cross the blood–brain barrier. To evaluate its potential applicability for the treatment of patients with central nervous system (CNS) tumors, we ...
Julia Benzel +10 more
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Cerebral energy metabolism and microdialysis in neurocritical care
Child's Nervous System, 2009 It is of obvious clinical importance to monitor cerebral metabolism--in particular, cerebral energy metabolism and indicators of cellular damage-online at the bedside. The technique of cerebral microdialysis provides the opportunity for continuous monitoring of metabolic changes in the tissue before they are reflected in peripheral blood chemistry or ...
Nordström, Carl-Henrik +2 more
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Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications [PDF]
Journal of Pharmacokinetics and Pharmacodynamics, 2013 The ability to deliver drug molecules effectively across the blood-brain barrier into the brain is important in the development of central nervous system (CNS) therapies. Cerebral microdialysis is the only existing technique for sampling molecules from the brain extracellular fluid (ECF; also termed interstitial fluid), the compartment to which the ...
Shannon, Richard J +4 more
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Discovery and validation of temporal patterns involved in human brain ketometabolism in cerebral microdialysis fluids of traumatic brain injury patientsResearch in context [PDF]
EBioMedicine, 2019 Background: Traumatic brain injury (TBI) is recognized as a metabolic disease, characterized by acute cerebral glucose hypo-metabolism. Adaptive metabolic responses to TBI involve the utilization of alternative energy substrates, such as ketone bodies ...
Michael Eiden +7 more
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Monitoring of cerebral blood flow and metabolism bedside in patients with subarachnoid hemorrhage - A Xenon-CT and microdialysis study. [PDF]
Frontiers in Neurology, 2014 Cerebral ischemia is the leading cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). Although 70% of the patients show angiographic vasospasm only 30% develop symptomatic vasospasm defined as Delayed cerebral ischemia ...
Elham eRostami +8 more
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Optical and Microdialysis Monitoring of Succinate Prodrug Treatment in a Rotenone-Induced Model of Mitochondrial Dysfunction in Swine [PDF]
MetabolitesBackground/Objectives: Mitochondrial dysfunction is a major cause of brain injury in patients with primary mitochondrial disease. New mitochondrial therapeutics and non-invasive tools for efficacy monitoring are urgently needed.
Alistair Lewis +7 more
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Cerebral microdialysis-based interventions targeting delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage [PDF]
Brain and Spine, 2022 J. Winberg +5 more
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