Results 41 to 50 of about 460,913 (180)

Increased Levels of Glutamate in Patients with Subarachnoid Haemorrhage as Measured by Intracerebral Microdialysis

, 1996
Cerebral ischemia associated with subarachnoid haemorrhage (SAH) may have severe consequences for neuronal function leading to reversible or permanent neurological deficits.
Säveland, H.,, Wieloch, T.,, Brandt, Lennart,, Nilsson, O. G.,, Lund University., Boris-Möller, F.,   +5 more
core   +2 more sources

Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches

Frontiers in Pharmacology, 2021
The impact of age and biological sex on outcome in moderate/severe traumatic brain injury (TBI) has been documented in large cohort studies, with advanced age and male sex linked to worse long-term outcomes.
C. Batson, A. Gomez, A. Gomez, A. S. Sainbhi, L. Froese, F. A. Zeiler, F. A. Zeiler, F. A. Zeiler, F. A. Zeiler, F. A. Zeiler   +9 more
doaj   +1 more source

Moderately prolonged permissive hypotension results in reversible metabolic perturbation evaluated by intracerebral microdialysis - an experimental animal study

Intensive Care Medicine Experimental, 2019
Background Damage control resuscitation (DCR) and damage control surgery (DCS) is the main strategy in patients with uncontrollable hemorrhagic shock. One aspect of DCR is permissive hypotension. However, the duration of hypotension that can be tolerated
Rasmus Peter Jakobsen, Troels Halfeld Nielsen, Simon Mølstrøm, Carl-Henrik Nordström, Asger Granfeldt, Palle Toft   +5 more
doaj   +1 more source

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Protective Effect of Buckwheat Polyphenols Against Long-Lasting Impairment of Spatial Memory Associated With Hippocampal Neuronal Damage in Rats Subjected to Repeated Cerebral Ischemia

Journal of Pharmacological Sciences, 2004
In the present experiment, we studied the action of buckwheat polyphenol (BWP, from Fagopyrum esculentum MOENCH) in a repeated cerebral ischemia model, which induced a strong and long-lasting impairment of spatial memory in 8-arm radial maze with ...
Fengling Pu, Kenichi Mishima, Nobuaki Egashira, Katsunori Iwasaki, Tomohiro Kaneko, Tomoko Uchida, Keiichi Irie, Daisuke Ishibashi, Hajime Fujii, Kenichi Kosuna, Michihiro Fujiwara   +10 more
doaj   +1 more source

The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D2 receptor occupancy in humans

British Journal of Clinical Pharmacology, EarlyView.
Aim Clozapine, used for treatment‐resistant schizophrenia, has a narrow therapeutic window and highly variable plasma pharmacokinetics (PK), necessitating careful monitoring. Direct measurement of unbound brain PK in humans is unethical. To develop a physiologically based pharmacokinetic–pharmacodynamic (PBPK‐PD) model to predict clozapine brain ...
Mengxu Zhang, Thomas I. F. H. Cremers, Vivi Rottschäfer, Elizabeth C. M. de Lange   +3 more
wiley   +1 more source

Actividades físico-deportivas y daño cerebral adquirido

, 2021
El presente documento recoge el resumen y las conclusiones de un taller sobre actividades físico-deportivas y daño cerebral adquirido (DCA). También para las personas con DCA, la práctica de actividades deportivas puede constituir un importante factor de
Federación Española de Daño Cerebral
core  

Plasma EC90 multiples are drug, target site and species specific—A physiologically based pharmacokinetic modelling example of nirmatrelvir central nervous system distribution

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Achieving minimum unbound drug concentration in plasma above in vitro EC90 is a common antiviral pharmacokinetic/pharmacodynamic (PK/PD) target. However, it often overlooks restricted distribution into target sites like the central nervous system (CNS), where a trough concentration above 1 × EC90 is needed.
Daan W. van Valkengoed, Xuanlin Liu, Sean N. Avedissian, Courtney V. Fletcher, Ashley N. Brown, Elizabeth C. M. de Lange, Anne‐Grete Märtson   +6 more
wiley   +1 more source

In-vitro gadolinium retro-microdialysis in agarose gel—a human brain phantom study

Frontiers in Radiology
Rationale and objectivesCerebral microdialysis is a technique that enables monitoring of the neurochemistry of patients with significant acquired brain injury, such as traumatic brain injury (TBI) and subarachnoid haemorrhage (SAH).
Chisomo Zimphango, Marius O. Mada, Marius O. Mada, Stephen J. Sawiak, Stephen J. Sawiak, Susan Giorgi-Coll, T. Adrian Carpenter, Peter J. Hutchinson, Peter J. Hutchinson, Keri L. H. Carpenter, Keri L. H. Carpenter, Matthew G. Stovell, Matthew G. Stovell   +12 more
doaj   +1 more source

In vivo microdialysis and in vitro HPLC analysis of the impact of paeoniflorin on the monoamine levels and their metabolites in the rodent brain

BioMedicine, 2019
Background: Paeoniflorin (PF) possesses several effects such as analgesic, the anti-spasmodic effect on smooth muscle. It protects the cardiovascular system and reveals the neuroprotective effect on cerebral ischemia. Monoamine system has been identified
Lin Yuh-Tzy, Huang Wei-Shih, Tsai Huei-Yann, Lee Min-Min, Chen Yuh-Fung   +4 more
doaj   +1 more source