Results 21 to 30 of about 460,913 (180)

Intracerebral Glutamate and Glycerol in Severe Acute Brain Injury: Retrospective Study of Association With Neuroworsening and Outcome. [PDF]

Acta Anaesthesiol Scand
ABSTRACT Background Glutamate is the main excitatory neurotransmitter in the brain, and extracellular levels of glutamate and glycerol (a breakdown product of cell damage) increase after severe acute brain injury. Previous studies report that increased intracerebral glutamate—measured using cerebral microdialysis (CMD)—is associated with unfavorable ...
Andreasen TH, Olsen MH, Vassilieva A, Fenger AW, Lund A, Jensen HR, Forsse A, Møller K.   +7 more
europepmc   +2 more sources

Current Approaches to Monitor Macromolecules Directly from the Cerebral Interstitial Fluid

Pharmaceutics, 2022
Gaining insights into the pharmacokinetic and pharmacodynamic properties of lead compounds is crucial during drug development processes. When it comes to the treatment of brain diseases, collecting information at the site of action is challenging.
Marie-Laure Custers, Liam Nestor, Dimitri De Bundel, Ann Van Eeckhaut, Ilse Smolders   +4 more
doaj   +1 more source

VMAT-DAT-Dopamine Regulatory System Involved in the Protective Effect of 3-n-Butylphthalide Against Ischemic Stroke. [PDF]

CNS Neurosci Ther
Proposed mechanism underlying NBP protection against ischemic stroke. NBP exerts neuroprotection against cerebral ischemic injury partially via upregulating the VMAT‐DAT‐dopamine cycle to improve synaptic dysfunction. Activation of D1R and adenosine A1Rs participates in the relevant downstream signalling cascades.
Zhou XT, Liu Q, Chen M, Zhang RX, Su YL, Su DF, Liu AJ.   +6 more
europepmc   +2 more sources

Monitoring Neurochemistry in Traumatic Brain Injury Patients Using Microdialysis Integrated with Biosensors: A Review

Metabolites, 2022
In a traumatically injured brain, the cerebral microdialysis technique allows continuous sampling of fluid from the brain’s extracellular space. The retrieved brain fluid contains useful metabolites that indicate the brain’s energy state.
Chisomo Zimphango, Farah C. Alimagham, Keri L. H. Carpenter, Peter J. Hutchinson, Tanya Hutter   +4 more
doaj   +1 more source

Glutamate, Microdialysis, and Cerebral Ischemia [PDF]

Anesthesiology, 2009
Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. By Helene Benveniste, Jørgen Drejer, Arne Schousboe, Nils H. Diemer. J Neurochem 1984; 43:1369-74. Reprinted with permission of Blackwell Publishing.
Helene Benveniste, David S. Warner
openaire   +2 more sources

Bedside microdialysis for detection of early brain injury after out-of-hospital cardiac arrest

Scientific Reports, 2021
Bedside detection and early treatment of lasting cerebral ischemia may improve outcome after out-of-hospital cardiac arrest (OHCA). This feasibility study explores the possibilities to use microdialysis (MD) for continuous monitoring of cerebral energy ...
Simon Mölström, Troels Halfeld Nielsen, Carl H. Nordström, Axel Forsse, Sören Möller, Sören Venö, Dmitry Mamaev, Tomas Tencer, Henrik Schmidt, Palle Toft   +9 more
doaj   +1 more source

Is cerebral microdialysis a clinical tool? [PDF]

Acta Neurochirurgica, 2012
Cerebral microdialysis has been utilised in a wide range ofcontexts for more than 20 years [5]. Nevertheless, despitethis longstanding experience and awealth of literature, it hasnot taken off as a routine clinical tool in many units. Bosserset al. provide a systematic review of the literature on cere-bral microdialysis, specifically in the context of ...
Adel, Helmy, Peter, Hutchinson
openaire   +2 more sources

Characterising the dynamics of cerebral metabolic dysfunction following traumatic brain injury: A microdialysis study in 619 patients.

PLoS ONE, 2021
Traumatic brain injury (TBI) is a major cause of death and disability, particularly amongst young people. Current intensive care management of TBI patients is targeted at maintaining normal brain physiology and preventing secondary injury.
Mathew R Guilfoyle, Adel Helmy, Joseph Donnelly, Matthew G Stovell, Ivan Timofeev, John D Pickard, Marek Czosnyka, Peter Smielewski, David K Menon, Keri L H Carpenter, Peter J Hutchinson   +10 more
doaj   +1 more source

Heart failure-induced reprogramming of salt-evoked neurovascular coupling in the rat hypothalamus. [PDF]

J Physiol
Abstract figure legend In sham rat, hypertonic saline induces activation of the AVP neurons, leading to dendritic AVP release and subsequent V1aR‐mediated PA vasoconstriction resulting in local tissue hypoxia in the SON. In heart failure rat, hypertonic saline similarly induces activation of the AVP neuron leading to dendritic AVP release.
Roy RK, Lira EC, Ongolo MB, Filosa JA, Stern JE.   +4 more
europepmc   +2 more sources

Cerebral microdialysis values in healthy brain tissue - a scoping review. [PDF]

Acta Neurochir (Wien)
Intracerebral microdialysis is an advanced method to guide clinicians during intensive care of patients with severe acute brain injury. Using intracerebral microdialysis, markers of brain metabolism and homeostasis can be analysed. Currently, trends are considered more important in clinical decision-making than absolute values.
Granerud IL, Fabritius ML, Jensen HR, Møller K, Sørensen MK.   +4 more
europepmc   +4 more sources