Results 51 to 60 of about 460,913 (180)

Effects of Reversal of Hypotension on Cerebral Microcirculation and Metabolism in Experimental Sepsis

Biomedicines, 2022
The effects of reversal of hypotension on the cerebral microcirculation, oxygenation, and metabolism in septic shock remain unclear. In 12 sheep, peritonitis was induced by injection of feces into the abdominal cavity.
Fabio Silvio Taccone, Fuhong Su, Xinrong He, Lorenzo Peluso, Katia Donadello, Sabino Scolletta, Daniel De Backer, Jean-Louis Vincent   +7 more
doaj   +1 more source

Spatiotemporal heterogeneity and dynamic evolution of microglial glucose metabolic reprogramming in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Alzheimer's disease (AD) is accompanied by persistent disturbances in brain energy metabolism, and microglial glucose metabolic reprogramming constitutes an important link among pathological protein deposition, neuroinflammation, and impaired clearance.
Yuan Chen, Fuyao Li, Junlei Zhang, Mingqing Wei, Jingnian Ni, Ting Li, Lulu Yao, Jinzhou Tian, Jing Shi   +8 more
wiley   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Consensus meeting on microdialysis in neurointensive care

, 2004
Background: Microdialysis is used in many European neurointensive care units to monitor brain chemistry in patients suffering subarachnoid hemorrhage (SAH) or traumatic brain injury (TBI).
Enblad, P, Olsen, Niels Vidiendal, Olsen, N V, Nordström, Carl-Henrik, B. Bellander, J. Sahuquillo, Bellander, B M, Robertson, C, Hutchinson, P, Robertson, Claudia, C. Robertson, A. Unterberg, Enblad, Per, Cantais, E, N. Stocchetti, Smith, M, N. Olsen, P. Enblad, P. Hutchinson, Nordström, Carl-Henrik,, Stocchetti, N, Unterberg, Andreas, C. Nordström, U. Ungerstedt, Sahuquillo, J, Unterberg, A, Bellander, Bo-Michael, Ungerstedt, Urban, Cantais, Emmanuel, Stocchetti, Nino, Sahuquillo, Juan, E. Cantais, Hutchinson, Peter, Smith, Martin Kruse, M. Smith, Lund University., Ungerstedt, U, Bellander, BM, Nordström, CH   +38 more
core   +1 more source

Central Nervous System Aspergillosis: Advances in Diagnosis, Therapeutics, and Multidisciplinary Management (2026 Update)

Mycoses, Volume 69, Issue 9, September 2026.
ABSTRACT Background Central nervous system (CNS) aspergillosis is a life‐threatening infection with mortality rates exceeding 50%, especially in immunocompromised patients. Significant challenges persist due to limited antifungal drug penetration into the CNS, emerging resistance, and diagnostic delays, despite advancements in therapy and diagnostics ...
Moustafa A. Mansour, Mohamed Wahid, Mohamed A. S. El Molla, Mohamed H. Helmy, Taha Mohammed Adel, Hamdi Nabawi Mostafa   +5 more
wiley   +1 more source

Evaluation of Caspase-1 Activation and IL-1β Production in A Kainic Acid Microdyalisis Brain Injury Model

Bio-Protocol, 2013
Intracerebral infusion of kainic acid (KA) by a microdialysis probe induces a focal swelling in the brain-perfused area which promotes inflammation (Compan et al., 2012; Oprica et al., 2003). The microdialysis technique allows the local in vivo perfusion
Antonio Herranz, Eulalia Bazán, Diana Reimers, María Montero-Vega, Adriano Jménez-Escrig, Pablo Pelegrín   +5 more
doaj   +1 more source

In Vivo Electrochemical Monitoring of Safinamide Pharmacokinetics in the Brain Explores Its Correlation With Vision‐Related Neuronal Activity

Advanced Science, Volume 13, Issue 43, 3 August 2026.
An electrochemical platform based on differential pulse amperometry enables real‐time, selective tracking of safinamide pharmacokinetics in the living brain with high spatiotemporal resolution. When integrated with electrophysiology, this approach reveals that drug‐induced suppression of vision‐related neuronal activity provides mechanistic insight ...
Xiaoke Nan, Chuqi Li, Qianhe Dai, Junlan Zhou, Lijiao Cao, Yuying Liu, Jinger Chen, Meiping Xiong, Yuhang Jiang, Xianchan Li   +9 more
wiley   +1 more source

The Correlation between Cerebral Blood Flow Measured by Bedside Xenon-CT and Brain Chemistry Monitored by Microdialysis in the Acute Phase following Subarachnoid Hemorrhage

Frontiers in Neurology, 2017
Cerebral microdialysis (MD) may be used in patients suffering from subarachnoid hemorrhage (SAH) to detect focal cerebral ischemia. The cerebral MD catheter is usually placed in the right frontal lobe and monitors the area surrounding the catheter.
Elham Rostami, Henrik Engquist, Henrik Engquist, Timothy Howells, Elisabeth Ronne-Engström, Pelle Nilsson, Lars Tomas Hillered, Anders Lewén, Per Enblad   +8 more
doaj   +1 more source

Elevated concentrations of macrophage migration inhibitory factor in serum and cerebral microdialysate are associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

Frontiers in Neurology, 2023
ObjectiveInflammation is increasingly recognized to be involved in the pathophysiology of aneurysmal subarachnoid hemorrhage (aSAH) and may increase the susceptibility to delayed cerebral ischemia (DCI).
Felix Neumaier, Felix Neumaier, Felix Neumaier, Christian Stoppe, Christian Stoppe, Christian Stoppe, Anzhela Stoykova, Miriam Weiss, Miriam Weiss, Michael Veldeman, Anke Höllig, Hussam Aldin Hamou, Yasin Temel, Catharina Conzen, Tobias Philip Schmidt, Rabia Dogan, Martin Wiesmann, Hans Clusmann, Gerrit Alexander Schubert, Gerrit Alexander Schubert, Roel Hubert Louis Haeren, Walid Albanna   +21 more
doaj   +1 more source

Cerebral metabolic effects of strict versus conventional glycaemic targets following severe traumatic brain injury

Critical Care, 2018
Background Optimal glycaemic targets for patients with severe traumatic brain injury remain unclear. The primary objective of this microdialysis study was to compare cerebral metabolism with strict versus conventional glycaemic control.
Mark P. Plummer, Natalia Notkina, Ivan Timofeev, Peter J. Hutchinson, Mark E. Finnis, Arun K. Gupta   +5 more
doaj   +1 more source