Results 261 to 270 of about 3,321,801 (325)

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Potential Association of BRCA Mutation and Lymphocytic Lobulitis. [PDF]

Clin Case Rep
Garg P, Park S, Ayeni FE, Edirimanne S.
europepmc   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Effect of dose-dense adjuvant chemotherapy in patients with node-positive early breast cancer according to estrogen receptor levels: an exploratory analysis of the GIM2 trial. [PDF]

Breast
De Angelis C, Rosa A, Delucchi V, Poggio F, Giuliano M, De Laurentiis M, Rimanti A, Turletti A, Vaccaro A, Fabi A, Gasparro S, Garrone O, Puglisi F, Cardinali B, Fregatti P, Lambertini M, Boni L, Blondeaux E, Del Mastro L.   +18 more
europepmc   +1 more source

Proteomic signatures identify significantly different inflammatory breast tissue microenvironments depending on mammographic density or estrogen exposure. [PDF]

NPJ Breast Cancer
Heenkenda MK, Abrahamsson A, Lundberg P, Dabrosin C.   +3 more
europepmc   +1 more source

Cost-effectiveness of abbreviated breast MRI and contrast-enhanced mammography for women with extremely dense breasts in a national breast cancer screening program: a micro-simulation study. [PDF]

Breast
Li M, Greuter MJW, Poelhekken K, Dorrius MD, Vermeulen KM, van Asselt ADI, de Bock GH.   +6 more
europepmc   +1 more source

Concordance of Digital Breast Tomosynthesis (DBT) and Magnetic Resonance Imaging (MRI) Measured Tumor Size with the Pathological Gold Standard: A Retrospective Cohort Analysis by Molecular Subtype and Breast Density. [PDF]

Diagnostics (Basel)
Eren A, Karatay E.
europepmc   +1 more source

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Supplemental Breast Cancer Screening in Women with Dense Breasts and Negative Mammography: A Systematic Review and Meta-Analysis.

Radiology, 2023
Background The best supplemental breast cancer screening modality in women at average risk or intermediate risk for breast cancer with dense breast and negative mammogram remains to be determined.
Heba Hussein, Engy Abbas, S. Keshavarzi, R. Fazelzad, K. Bukhanov, S. Kulkarni, F. Au, S. Ghai, A. Alabousi, V. Freitas   +9 more
semanticscholar   +1 more source

Breast Cancer in Dense Breasts: Detection Challenges and Supplemental Screening Opportunities.

Radiographics, 2023
Dense breast tissue at mammography is associated with higher breast cancer incidence and mortality rates, which have prompted new considerations for breast cancer screening in women with dense breasts. The authors review the definition and classification
Ann L Brown, C. Vijapura, Mitva J. Patel, Alexis De La Cruz, R. Wahab   +4 more
semanticscholar   +1 more source