Results 81 to 90 of about 217,760 (286)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

AN AUTOMATIC FILTER ALGORITHM FOR DENSE IMAGE MATCHING POINT CLOUDS [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2017
Although many filter algorithms have been presented over past decades, these algorithms are usually designed for the Lidar point clouds and can’t separate the ground points from the DIM (dense image matching, DIM) point clouds derived from the oblique ...
Y. Q. Dong, Y. Q. Dong, L. Zhang, X. M. Cui, H. B. Ai   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Building Change Detection from Historical Aerial Photographs Using Dense Image Matching and Object-Based Image Analysis

Remote Sensing, 2014
A successful application of dense image matching algorithms to historical aerial photographs would offer a great potential for detailed reconstructions of historical landscapes in three dimensions, allowing for the efficient monitoring of various ...
Stephan Nebiker, Natalie Lack, Marianne Deuber   +2 more
doaj   +1 more source

FrameNet: Learning Local Canonical Frames of 3D Surfaces from a Single RGB Image

, 2019
In this work, we introduce the novel problem of identifying dense canonical 3D coordinate frames from a single RGB image. We observe that each pixel in an image corresponds to a surface in the underlying 3D geometry, where a canonical frame can be ...
Funkhouser, Thomas, Guibas, Leonidas, Huang, Jingwei, Zhou, Yichao   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

STEREO IMAGE DENSE MATCHING BY INTEGRATING SIFT AND SGM ALGORITHM [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2018
Semi-global matching(SGM) performs the dynamic programming by treating the different path directions equally. It does not consider the impact of different path directions on cost aggregation, and with the expansion of the disparity search range, the ...
Y. Zhou, Y. Song, J. Lu
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dense image matching for close range photogrammetry

, 2016
Dichte Bildzuordnung ermöglicht die Berechnung von 3D Oberflächen aus mindestens zwei Bildern durch die Lösung des Korrespondenzproblems für jedes Pixel. Anhand der Korrespondenzinformation und der bekannten Kamerageometrie kann die Tiefeninformation durch einen Schnitt der Sichtstrahlen im Raum rekonstruiert werden.
openaire   +3 more sources