Results 201 to 210 of about 164,722 (302)

Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants

The FEBS Journal, EarlyView.
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan, Jafar S. Jabbari, Naomi X. L. Ling, Anne M. Kong, Jia Q. Truong, Marnie L. Maddock, Ayeshah A. Rosdah, Christopher G. Langendorf, Lifang Zhang, Jarmon G. Lees, Sebastian Bass‐Stringer, Danise Ann Onda, Alice Pébay, Mirella Dottori, Kim Loh, Jessica K. Holien, Sean Lal, Nadia M. Davidson, Jonathan S. Oakhill, Shiang Y. Lim   +19 more
wiley   +1 more source

Alteration of gut microbiota contributes to peritoneal fibrosis through increased production of trimethylamine N-oxide. [PDF]

Gut Microbes
Xie W, Yuan J, Feng C, Shi H, Zhang C, Xi T, Huang J, Fang W, Ni Z, Gu L, Jiang N.   +10 more
europepmc   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

Correction to: Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells. [PDF]

Br J Cancer
Dixon KM, Lui GYL, Kovacevic Z, Zhang D, Yao M, Chen Z, Dong Q, Assinder SJ, Richardson DR.   +8 more
europepmc   +1 more source

Thriving in Nursing Work: The Association Between Self‐Reports and Biomarkers of Stress, Inflammation and Neuroplasticity

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To examine whether self‐reported thriving at work is associated with biomarkers of stress, inflammation, neuroplasticity and neurodegeneration in nurses. Design A cross‐sectional study. Methods An online questionnaire measuring thriving at work was administered to nurses in a teaching hospital in Michigan, U.S. over 5 weeks in 2024.
Judith E. Arnetz, Eamonn Arble, Jackeline Iseler, Michelle Pena, Nicolina Evola, John Vanschagen, John S. Beck, Scott E. Counts, Bengt B. Arnetz   +8 more
wiley   +1 more source

HCMV-pUS2 Disrupts cGAS-STING Signaling through LMAN2L Degradation. [PDF]

PLoS Pathog
Zhou YP, Yao YX, Wu JP, Pan YT, Zeng WB, Sun JY, Zhao Y, Cheng H, Luo MH, Yang B.   +9 more
europepmc   +1 more source

Scratching beneath the surface: Quantification of muscle architecture and myosin heavy chain content in the forelimbs of black‐tailed prairie dogs (Cynomys, Rodentia)

Journal of Anatomy, EarlyView.
Black‐tailed prairie dogs are highly social ground squirrels that excavate communal burrow systems, most often in medium‐textured soils. Their forelimbs demonstrate morphofunctional trade‐offs for scratch‐digging and terrestrial ecology, including well‐developed and fast‐contracting proximal musculature with large mechanical advantage paired with ...
Luke A. Scheetz, Carter A. Burnett, Benjamin R. Kimble, David A. Eads, Michael T. Butcher   +4 more
wiley   +1 more source

Impact of Superficial Keratectomy on Corneal Topography, Aberration, and Densitometry in Salzmann Nodular Degeneration. [PDF]

J Clin Med
Qi Z, Mukhija R, Quiney G, Nanavaty MA.
europepmc   +1 more source

Regulation of the Yersinia pseudotuberculosis Type III Secretion System by the CpxAR Two‐Component System

Molecular Microbiology, EarlyView.
Host tissue cues including temperature, oxygen, and iron availability regulate expression of the Yersinia type III secretion system (T3SS) master regulator LcrF. We found that CpxR inhibits LcrF through an indirect, multi‐factorial mechanism and identified the osmolarity‐sensing OmpR/EnvZ system as an additional regulator of LcrF, highlighting ...
Karen Hug, Erin Mettert, Melissa Estrada Escobar, Cristina Vargas Vazquez, David Balderas, Sarvind Tripathi, Laya Ashley, Patricia J. Kiley, Victoria Auerbuch   +8 more
wiley   +1 more source

APOE4-Expressing Astrocytes Exhibit Parkinson's Disease-Related Pathology. [PDF]

Mol Neurobiol
Lior N, Anna P, Roni H, Daniel MM, Dan F, Ronit PK.   +5 more
europepmc   +1 more source