Results 301 to 310 of about 252,175 (379)

Distinct profiles of mitochondrial bioenergetics and redox balance in left atrial and ventricular myocardium in the healthy rat heart

Experimental Physiology, EarlyView.
Abstract The left ventricle (LV) is the primary pumping chamber of the heart, generating high systolic pressure to sustain systemic circulation. LV contractile dysfunction is a hallmark of various cardiovascular diseases and is associated with mitochondrial dysfunction, characterised by decreased oxidative phosphorylation (OXPHOS) capacity and ...
Tingting Fang, Alex Chan, Janice Chew‐Harris, Toan Pham   +3 more
wiley   +1 more source

TRAIL-resistant glioma cells resist Withania somnifera mediated apoptosis via USP5 upregulation. [PDF]

Sci Rep
Bhardwaj S, Yadav AK.
europepmc   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

Results of relugolix/estradiol/norethisterone acetate combination therapy in real-world clinical practice: Effectiveness, tolerability, and factors influencing discontinuation. [PDF]

Eur J Obstet Gynecol Reprod Biol X
Santalla-Hernández A, Naveiro-Fuentes M, Esquinas-Orellana N, Benítez-Cejas LM, García-Rivera M, Fernández-Parra J.   +5 more
europepmc   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

The Journal of Physiology, EarlyView.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese, G. Joudah, I. P. Salt, J. R. Petrie, J. M. Leiper, Laura B. Dowsett   +5 more
wiley   +1 more source

Soluble CSF1R alleviates microgliopathy in a CSF1R-related leukoencephalopathy (CRL) mouse model. [PDF]

J Neuroinflammation
Zhou Y, Hu B, Luo J, Wang X, Huang X, Li Y, Zhang X, Bu G, Zhang H, Zhang YW, Zheng H.   +10 more
europepmc   +1 more source

Deregulation of m6A-RNA methylation impairs adaptive hypertrophic response and drives maladaptation via mTORC1-S6K1-hyperactivation and autophagy impairment. [PDF]

Cell Commun Signal
Annamalai K, Dilliker S, Buchholz E, Castro-Hernández R, Panyam N, Pommeranz A, Wiederhake P, Wery von Limont N, Hempel N, Ebner V, Swarnkar S, Mohamed BA, Streckfuss-Bömeke K, Steffens S, Herzig S, Ebert A, Fischer A, Toischer K.   +17 more
europepmc   +1 more source

Roxadustat alleviates cisplatin-induced acute kidney injury by regulating fatty acid oxidation and mitochondrial function. [PDF]

Ren Fail
Li X, Hu Y, Li J, Shi Y, Zhong Q, Ma X, Jiang D, Zhang S, Zhuang S, Liu N.   +9 more
europepmc   +1 more source

A quantitative assessment of the corneal endothelium and transparency after Kahook dual blade goniotomy combined with phacoemulsification. [PDF]

Indian J Ophthalmol
Asfuroğlu M, Asfuroğlu Y, Fikret CZ.
europepmc   +1 more source