Results 141 to 150 of about 13,002,222 (403)
Diffeomorphic density registration
, 2018 In this book chapter we study the Riemannian Geometry of the density registration problem: Given two densities (not necessarily probability densities) defined on a smooth finite dimensional manifold find a diffeomorphism which transforms one to the other.
Ashburner +41 more
core +1 more source
FEBS Letters, EarlyView.We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon +5 more
wiley +1 more source
Ions in solution: Density Corrected Density Functional Theory (DC-DFT)
, 2014 Standard density functional approximations often give questionable results for odd-electron radical complexes, with the error typically attributed to self-interaction.
Eunji Sim +5 more
core +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Minimum Density Hyperplanes [PDF]
, 2016 Associating distinct groups of objects (clusters) with contiguous regions of high probability density (high-density clusters), is central to many statistical and machine learning approaches to the classification of unlabelled data.
Hofmeyr, David P. +2 more
core +2 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Enhanced proton acceleration in an applied longitudinal magnetic field
New Journal of Physics, 2016 Using two-dimensional particle-in-cell simulations, we examine how an externally applied strong magnetic field impacts proton acceleration in laser-irradiated solid-density targets. We find that a kT-level external magnetic field can sufficiently inhibit
A Arefiev, T Toncian, G Fiksel
doaj +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Proceedings of the American Mathematical Society, 1971 We prove that for any r r , “ entropy = r \operatorname {entropy} = r ” is a dense condition in the uniform topology.
openaire +2 more sources
International Journal of Behavioral Nutrition and Physical Activity, 2018 Furthermore, these errors were mistakenly introduced by the Production team managing this article and, as such were not the fault of the authors.
Thomas Burgoine +3 more
doaj +1 more source