Results 71 to 80 of about 3,098,507 (269)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Effects of Aging and Dual-Task Demands on the Comprehension of Less Expected Sentence Continuations: Evidence From Pupillometry

Frontiers in Psychology, 2019
Prior studies on language processing in aging have shown that older adults experience integration difficulties for contextually unpredictable target words (as indicated by low cloze probabilities in prior ratings), and that such comprehension ...
Katja I. Häuser, Katja I. Häuser, Vera Demberg, Vera Demberg, Jutta Kray, Jutta Kray   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Localized Reluctivity Stabilization of Hysteresis Model for Transient Finite Element Simulation of Ferromagnetic Materials

Eng
The hysteresis model can be used to accurately predict the magnetic hysteresis characteristics of ferromagnetic materials. Incorporating the hysteresis model into finite element calculations enables precise prediction of field distributions, voltage or ...
Xiaotong Fu, Shuai Yan, Yaxing Zhou, Zhifu Chen, Xiaoyu Xu, Zhuoxiang Ren   +5 more
doaj   +1 more source

Residential greenness and prevalence of major depressive disorders: a cross-sectional, observational, associational study of 94 879 adult UK Biobank participants

The Lancet Planetary Health, 2018
Summary: Background: Increased urbanisation and the associated reduced contact of individuals with natural environments have led to a rise in mental disorders, including depression.
Chinmoy Sarkar, PhD, Chris Webster, ProfDSc, John Gallacher, ProfPhD   +2 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Causal Effect of Leading-Edge Sawtooth Configuration on Flow Field Characteristics and Aerodynamic Losses in the Supersonic Compressor Cascade [PDF]

Journal of Applied Fluid Mechanics
This study focuses on the TM-141 supersonic compressor blade as the subject of investigation. Utilizing the Reynolds-averaged numerical simulation approach, the study examines the impact of the leading-edge sawtooth structure on the blade grid, flow ...
S. J. Hu, Z. J. Wei, M. Ni, G. M. Ren
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Control Strategy for Hybrid Magnetic Bearing Based on Improved Cascaded Reduced-Order Active Disturbance Rejection Controller

CES Transactions on Electrical Machines and Systems
During the startup of the hydraulic turbine generators, the hybrid magnetic bearing support system exhibits displacement fluctuations, and the nonlinearity and strong coupling characteristics of the magnetic bearings limit the accuracy of rotor modeling,
Kaiyu Shan, Ke Wang, Wei Zhang, Yuxiang Zhu, Lu Zhao, Jinquan Zhu   +5 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source